Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/NC/Charlotte
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Charlotte, NC

Studies commonly pay $75 to $4,500 per completed study

648 clinical trials are currently recruiting participants within 30 miles of Charlotte. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

648studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Charlotte right now

Top 25 of 648 recruiting studies, sorted by proximity — each links to its official registry page

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Carolina Oncology Specialists, PA ( Site 9002) — Charlotte, North Carolina (1.5 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Phase 1 Interventional 36 participants sought
Atrium Health Levine Cancer Institute - Morehead — Charlotte, North Carolina (1.5 mi) · Sponsor: PeproMene Bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05370430)

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

Uncontrolled Hypertension Phase 2 Interventional 280 participants sought
Retension Clinical Site — Charlotte, North Carolina (1.5 mi) · Sponsor: Retension Pharmaceuticals. Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07142356)

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

Knee Cartilage Defects Phase 3 Interventional 300 participants sought
Atrium Health Mercy — Charlotte, North Carolina (1.5 mi) · Sponsor: Medipost, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07339111)

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

Aortoiliac Occlusive Disease N/A Observational 158 participants sought
Atrium Health Sanger Heart & Vascular Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: W.L.Gore & Associates
See eligibility & contact on ClinicalTrials.gov (NCT06872905)

Depemokimab as an Extended treatmeNt Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA -1)

Pulmonary Disease, Chronic Obstructive Phase 3 Interventional 981 participants sought
GSK Investigational Site — Rock Hill, South Carolina (22.5 mi) · Sponsor: GlaxoSmithKline
See eligibility & contact on ClinicalTrials.gov (NCT06959095)

A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

Non-Muscle Invasive Bladder Neoplasms N/A Observational 150 participants sought
Urology Specialists of the Carolinas PLLC Charlotte — Charlotte, North Carolina (1.5 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07309445)

A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4)

Relapsed Refractory Multiple Myeloma Phase 3 Interventional 508 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07391657)

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

Solid Tumor, Advanced Cancer Phase 1 Interventional 330 participants sought
Carolina BioOncology Institute — Huntersville, North Carolina (14.0 mi) · Sponsor: I-Mab Biopharma US Limited
See eligibility & contact on ClinicalTrials.gov (NCT04900818)

A Study to Assess the Safety and Efficacy of Different Doses of ELV001 to Treat Active Rheumatoid Arthritis in Patients With an Inadequate Response to Methotrexate and Tumor Necrosis Factor Inhibition (START SYNERGY)

Active Rheumatoid Arthritis Phase 2 Interventional 180 participants sought
DJL Clinical Research PLLC (Network) cIRB — Charlotte, North Carolina (1.5 mi) · Sponsor: Elevara Medicines Limited
See eligibility & contact on ClinicalTrials.gov (NCT07409103)

A Prospective, Randomized, Single-blind, Controlled, Multi-center Study to Assess the Safety and Performance of MagnetOsTM Compared to Autogenous Bone Graft in Patients Undergoing Hindfoot or Ankle Fusions.

Ankle Arthrodesis or Arthroplasty, Hindfoot Fusion N/A Interventional 126 participants sought
OrthoCarolina Research Institute, Inc — Charlotte, North Carolina (1.5 mi) · Sponsor: Kuros Biosurgery AG
See eligibility & contact on ClinicalTrials.gov (NCT07225751)

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

Polymyositis, Dermatomyositis Phase 3 Interventional 240 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06455449)

A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

Recurrent or Metastatic Solid Tumors Phase 1 Interventional 76 participants sought
Research Site — Charlotte, North Carolina (1.5 mi) · Sponsor: Daiichi Sankyo
See eligibility & contact on ClinicalTrials.gov (NCT07015697)

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Solid Tumors, Lymphoma Phase 2 Interventional 40 participants sought
Carolinas Medical Center/ Levine Children's Hospital — Charlotte, North Carolina (1.5 mi) · Sponsor: Spectrum Pharmaceuticals, Inc
See eligibility & contact on ClinicalTrials.gov (NCT04570423)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma Phase 3 Interventional 380 participants sought
Atrium Health Levine Cancer Institute /ID# 246199 — Charlotte, North Carolina (1.5 mi) · Sponsor: AbbVie
See eligibility & contact on ClinicalTrials.gov (NCT06158841)

A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

Advanced Solid Tumor, Refractory Non-Hodgkin Lymphoma Phase 1 Interventional 80 participants sought
Carolina BioOncology — Huntersville, North Carolina (14.0 mi) · Sponsor: FBD Biologics Limited
See eligibility & contact on ClinicalTrials.gov (NCT05892718)

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 93 participants sought
Carolinas Medical Center/Levine Cancer Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06672146)

The GORE® VIABAHN® FORTEGRA Venous Stent Iliofemoral Study

Venous Thromboses, Venous Disease N/A Interventional 165 participants sought
Atrium Health-Sanger Heart and Vascular Institute — Charlotte, North Carolina (1.5 mi) · Sponsor: W.L.Gore & Associates
See eligibility & contact on ClinicalTrials.gov (NCT05489588)

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

Breast Neoplasms Phase 3 Interventional 558 participants sought
Oncology Specialists of Charlotte Pa — Charlotte, North Carolina (1.5 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT07173751)

A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated With SureSmile® Aligners.

Malocclusion N/A Interventional 90 participants sought
J Chichetti PLLC 2 — Huntersville, North Carolina (14.0 mi) · Sponsor: Dentsply Sirona Implants and Consumables
See eligibility & contact on ClinicalTrials.gov (NCT07290790)
Google-rated

Top-rated research centers in Charlotte

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Queen City Clinical Research, PLLC

330 Billingsley Rd Ste 206?, Charlotte, NC 28211
(704) 405-3150

New Hope Clinical Research, Inc.

★ 4.2
3101 Latrobe Dr, Charlotte, NC 28211
(980) 209-9784
"They called to screen me and I’m not even depressed. Just lied because I need the money. I’m sure they haven’t called a bunch of others like they cal…"
— Pluto Enterprises LLC, 3★

DJL Clinical Research, PLLC

★ 5.0
431 N Wendover Rd, Charlotte, NC 28211
(704) 247-9179
"Was in a study with DJL Research for 4+ years. An experience I entered with apprehension thinking I'd be treated like a #, and quickly felt like I w…"
— margaret frantz, 5★

New Hope Speciality Clinic

★ 3.5 (19 reviews)
3101 Latrobe Dr, Charlotte, NC 28211
(704) 817-8331
"STAY AWAY! Medication not called in to pharmacy in a timely manner. Phone calls not answered. Phone calls not returned. This facility is just UNPR…"
— Ann Fern, 1★

Carolinas Research Center

★ 5.0
1805 Milton Rd # B, Charlotte, NC 28215
(704) 595-7887

DelRicht Research | Charlotte Clinical Trials

★ 4.8
6719 Fairview Rd Ste A, Charlotte, NC 28210
(704) 644-8469
"The team members are kind and considerate. They will answer questions and provide you with feedback you can share with your primary provider. Super P…"
— Kenya Davis, 5★

Rose Research Center

★ 4.9
8401 Medical Plaza Dr #275, Charlotte, NC 28262
(704) 350-2999
"I had an excellent experience I am definitely team Mary Beth and team rejoice definitely five stars for the ladies"
— Griselda Crawford, 5★

OrthoCarolina Research Institute, Inc.

★ 5.0
2001 Vail Ave #300, Charlotte, NC 28207
(704) 945-7710
"Outstanding experience with doctors, staff, nurses...."
— JamesRichard Smutney, 5★

Catawba Research, LLC

★ 5.0
5200 77 Center Dr #160, Charlotte, NC 28217
(980) 242-3980

Clinical trials in Charlotte: what's recruiting

The Charlotte area currently has 648 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Charlotte, the most active research areas are:

  • Cancer & Oncology10 studies
  • Immune & Skin2 studies
  • Liver & Kidney1 studies
  • Heart & Vascular1 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Charlotte, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Charlotte

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Charlotte participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Charlotte safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Charlotte, NC?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Charlotte?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Charlotte?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Charlotte.

Paid clinical trials near Charlotte

Other metros within reach

Concord, NC630 Rock Hill, SC587 Gastonia, NC650 Hickory, NC92 Winston-Salem, NC602 Spartanburg, SC367 High Point, NC602 Columbia, SC201

More of NC

Durham1,671 Cary1,671 Raleigh1,662 Burlington761 Gastonia650 Concord630 High Point602 Winston-Salem602 Greensboro601 Asheville121 Fayetteville115

New paid studies open every week

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