Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/TN/Knoxville
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Knoxville, TN

Studies commonly pay $75 to $4,500 per completed study

223 clinical trials are currently recruiting participants within 30 miles of Knoxville. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

223studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Knoxville right now

Top 25 of 223 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Tennessee Cancer Specialists — Knoxville, Tennessee (1.7 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Southeastern Retina Associates, P.C. — Knoxville, Tennessee (1.7 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

Feasibility, Safety and Efficacy of Nebulized Long-Acting Bronchodilators (Formoterol and Revefenacin) vs. Short-Acting Bronchodilators (Albuterol and Ipratropium) in Hospitalized Patients With AECOPD

COPD Exacerbation Phase 4 Interventional 60 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT04655170)

Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance

Barrett Esophagus, Barretts Esophagus With Dysplasia N/A Interventional 2,298 participants sought
Gastrointestinal Associates, PC — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Colorado, Denver
See eligibility & contact on ClinicalTrials.gov (NCT05530343)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute UVA Exposure on Eyes With Ectatic Corneal Diseases

Keratoconus, Ectasia of Cornea Phase 3 Interventional 485 participants sought
Woolfson Eye Institute — Knoxville, Tennessee (1.7 mi) · Sponsor: Woolfson Eye Institute
See eligibility & contact on ClinicalTrials.gov (NCT07124910)

A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

Staphylococcus Aureus Phase 1, Phase 2 Interventional 231 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06749457)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
University of Tennessee - Knoxville — Knoxville, Tennessee (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant Phase 3 Interventional 800 participants sought
Tennessee Cancer Specialists — Knoxville, Tennessee (1.7 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07225946)

Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

Down Syndrome (DS), Keratoconus Phase 3 Interventional 225 participants sought
Woolfson Eye Institute — Knoxville, Tennessee (1.7 mi) · Sponsor: Woolfson Eye Institute
See eligibility & contact on ClinicalTrials.gov (NCT07135167)

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer Phase 3 Interventional 4,300 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05774951)

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma Phase 3 Interventional 62 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05235165)

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma Phase 2 Interventional 80 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT02981628)

REVASC-PAD: REstricted VASCular Exercise for Peripheral Arterial Disease - A Feasibility Study at University of Tennessee Medical Center

Peripheral Arterial Disease N/A Interventional 81 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT07223437)

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

Non-small Cell Lung Cancer Phase 2, Phase 3 Interventional 1,260 participants sought
University of Tennessee Medical Center — Knoxville, Tennessee (1.7 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT06712316)

Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

Breast Cancer Phase 3 Interventional 750 participants sought
Tennessee Cancer Specialists — Knoxville, Tennessee (1.7 mi) · Sponsor: Greenwich LifeSciences, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05232916)

Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids

Asthma Phase 2 Interventional 540 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06932263)

Planning Together: A Couple-based, Multi-level Prenatal Contraceptive Education Program for Economically Marginalized Families

Short Interpregnancy Intervals, Maternal Health Disparities N/A Interventional 60 participants sought
University of Tennessee Graduate School of Medicine — Knoxville, Tennessee (1.7 mi) · Sponsor: University of Tennessee Graduate School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT07214012)

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Breast Cancer, Locally Advanced Breast Cancer Phase 3 Interventional 1,000 participants sought
Clinical Trial Site — Knoxville, Tennessee (1.7 mi) · Sponsor: Olema Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07085767)

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Non Small Cell Lung Cancer Phase 3 Interventional 780 participants sought
University of Tennessee Medical Center Knoxville ( Site 0082) — Knoxville, Tennessee (1.7 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06312137)

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

Acute Myeloid Leukemia, Recurrent Acute Myeloid Leukemia Phase 3 Interventional 556 participants sought
East Tennessee Childrens Hospital — Knoxville, Tennessee (1.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT07022678)

A Phase III Study to Investigate the Efficacy and Safety of Elecoglipron Alone or in Combination With Dapagliflozin Compared With Placebo in Adults With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus Phase 3 Interventional 800 participants sought
Research Site — Knoxville, Tennessee (1.7 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07662044)
Google-rated

Top-rated research centers in Knoxville

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

AMR Clinical

★ 4.0
1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784

New Phase Research & Development

★ 4.8
6914 Office Pk Cir NW, Knoxville, TN 37909
(865) 200-8364
"Amazing group of people. Kind and friendly! Willing to work with you through any scenario!"
— Trudy Honest, 5★

Accellacare Research of Knoxville

★ 3.3
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"STOP. This business is a scam. They probe for private info. Make you an appt, then call you 3 hrs before appt and a reason to disqualify you. My fear…"
— Elaine Sharp, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 3.3
4th & 5th Floors, North Tower, 1924 Alcoa Hwy, Knoxville, TN 37920
(865) 305-3784
"Participant beware!! I would never do another in-house study with AMR. Their in-house location is in one of the oldest buildings of the UT hospital, …"
— Vivver, 1★

AMR Knoxville / Volunteer Research Group (VRG)

★ 4.6
801 N Weisgarber Rd Ste 100, Knoxville, TN 37909
(865) 305-3784
"I was pre-screened via telephone and told I was eligible for a study. I was told that they needed to determine how to enroll me and would get back to…"
— Kristin Stone, 1★

Alliance for Multispecialty Research

801 N Weisgarber Rd, Knoxville, TN 37909
(615) 591-0211

NOCCR Knoxville

★ 3.6
1924 Alcoa Highway 4th and 5th Floors North Tower, Knoxville, TN 37920
(865) 305-3784
"The nurses here are trash, and the facility is bunk."
— Jarrod Glass, 1★

PMG Research of Knoxville

★ 3.7
1200 Merchant Dr, Knoxville, TN 37912
(865) 244-4276
"I tried calling that place I don't know how many times and I can't get ahold of anyone at the place I have question I need to ask but nobody there wi…"
— MaZe Clan, 1★

University of Tennessee Research Foundation

★ 3.5
UT Tower, 400 W Summit Hill Dr SW Ste 961A, Knoxville, TN 37902
(865) 974-1882
"The answer all by questions correctly"
— Evelyn Robinson, 2★

Clinical trials in Knoxville: what's recruiting

The Knoxville area currently has 223 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Knoxville, the most active research areas are:

  • Cancer & Oncology12 studies
  • Diabetes & Metabolism2 studies
  • Lungs & Breathing2 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Knoxville, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Knoxville

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Knoxville participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Knoxville?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Knoxville safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Knoxville, TN?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Knoxville?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Knoxville.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Knoxville typically complete one or two studies per year.

Paid clinical trials near Knoxville

Other metros within reach

Asheville, NC121 Chattanooga, TN146 Gainesville, GA149 Greenville, SC382 Mauldin, SC382 Athens, GA69 Lexington, KY467 Atlanta, GA1,673

More of TN

Nashville1,336 Memphis578 Chattanooga146 Murfreesboro79 Clarksville9

New paid studies open every week

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