Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/ME/Portland
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Portland, ME

Studies commonly pay $75 to $4,500 per completed study

167 clinical trials are currently recruiting participants within 30 miles of Portland. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

167studies recruiting
9+research centers nearby
3condition categories
Live from the NIH registry

Studies recruiting near Portland right now

Top 25 of 167 recruiting studies, sorted by proximity — each links to its official registry page

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Maine Eye Center — Portland, Maine (1.5 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
New England Cancer Specialists ( Site 0132) — Westbrook, Maine (5.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)

Non-Traumatic Subarachnoid Hemorrhage Phase 4 Interventional 20 participants sought
MaineHealth — Portland, Maine (1.5 mi) · Sponsor: Madeleine Puissant
See eligibility & contact on ClinicalTrials.gov (NCT06569212)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 93 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06672146)

ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer

Breast Neoplasms Phase 3 Interventional 558 participants sought
New England Cancer Specialists — Westbrook, Maine (5.0 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT07173751)

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

Endometrial Cancer Phase 1, Phase 2 Interventional 148 participants sought
Maine Medical Center — Scarborough, Maine (7.3 mi) · Sponsor: Alliance Foundation Trials, LLC.
See eligibility & contact on ClinicalTrials.gov (NCT04486352)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
MaineHealth Maine Medical Center- Scarborough — Scarborough, Maine (7.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer Phase 3 Interventional 4,300 participants sought
Research Site — Scarborough, Maine (7.3 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05774951)

AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia

Community-acquired Pneumonia Phase 3 Interventional 4,000 participants sought
Maine Medical Centre — Portland, Maine (1.5 mi) · Sponsor: University of Manitoba
See eligibility & contact on ClinicalTrials.gov (NCT05848713)

A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

Endometrial Cancer Phase 3 Interventional 1,123 participants sought
Maine Medical Center - Scarborough Campus ( Site 6042) — Scarborough, Maine (7.3 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06952504)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma Phase 3 Interventional 62 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05235165)

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma Phase 2 Interventional 80 participants sought
Maine Children's Cancer Program — Scarborough, Maine (7.3 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT02981628)

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Breast Carcinoma, Colorectal Carcinoma N/A Observational 2,000 participants sought
MaineHealth Cancer Care and IV Therapy - South Portland — South Portland, Maine (2.9 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT06418204)

Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Breast Cancer, Locally Advanced Breast Cancer Phase 3 Interventional 1,000 participants sought
Clinical Trial Site — Scarborough, Maine (7.3 mi) · Sponsor: Olema Pharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07085767)

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Non Small Cell Lung Cancer Phase 3 Interventional 780 participants sought
New England Cancer Specialists ( Site 0095) — Westbrook, Maine (5.0 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06312137)

Genomically Profiling, Collecting, Archiving and Distributing Hematologic Malignancy Specimens

Leukemia, Myelodysplastic Syndromes N/A Observational 300 participants sought
Maine Medical Center — Portland, Maine (1.5 mi) · Sponsor: Dana-Farber Cancer Institute
See eligibility & contact on ClinicalTrials.gov (NCT04968834)

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

Ovarian Neoplasms, Fallopian Tube Neoplasms Phase 3 Interventional 1,630 participants sought
Maine Medical Center - Scarborough Campus — Scarborough, Maine (7.3 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07213804)

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System Phase 1 Interventional 47 participants sought
MaineHealth Maine Medical Center - Portland — Portland, Maine (1.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04609046)

International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry

Gaucher Disease, Cerebroside Lipidosis Syndrome N/A Observational 12,000 participants sought
Maine Medical Partners Pediatric Specialty Care- Site Number : 840064 — Portland, Maine (1.5 mi) · Sponsor: Genzyme, a Sanofi Company
See eligibility & contact on ClinicalTrials.gov (NCT00358943)
Google-rated

Top-rated research centers in Portland

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

MaineHealth Institute for Research

★ 5.0
81 Research Drive, Scarborough, ME 04074
(207) 396-8100
"They do a lot of great research here and the people are great to work with!"
— Teresa Martel, 5★

MaineHealth Hannaford Center for Safety, Innovation and Simulation

335 Brighton Ave Fl 3, Portland, ME 04102
(207) 662-7060

Compass Mental Health Maine LLC

251 Woodford St, Portland, ME 04103
(207) 773-2828

Portland Gastroenterology Center

★ 4.5
161 Marginal Way, Portland, ME 04101
(207) 773-7964
"Dr Vecchio is wonderful and ive now met 2 of the other providers who seem very nice as well. They seem to actually care and want to find solutions fo…"
— Laurie, 5★

MaineHealth Cancer Care and Blood Disorders - Scarborough

★ 4.5
100 Campus Dr Unit 108, Scarborough, ME 04074
(207) 303-1100
"Amazing Group!<br>I took my sister for her chemotherapy treatment today, and I was so impressed with ALL of the staff. Every person we interacted wit…"
— Liz L, 5★

MaineHealth Cancer Risk and Prevention - Scarborough

100 Campus Dr Suite 121, Scarborough, ME 04074
(207) 396-7785

MaineHealth Bleeding Disorders - Scarborough

100 Campus Dr #107, Scarborough, ME 04074
(844) 504-9680

MaineHealth - Scarborough Campus

★ 3.8
100 Campus Dr, Scarborough, ME 04074
"Dr Febrraro is a wonderful Gynecological Oncologist. I had cancer surgery and couldn't have been more pleased. She has me come for a checkup every 6 …"
— MarieElena Mathena, 5★

CIEE: Council on International Educational Exchange

★ 3.9
600 Southborough Dr Ste 104, South Portland, ME 04106
(207) 553-4000
"I had a great time studying abroad, no complaints with the team at my location. However their main office has the slowest response time I have ever d…"
— Ada S, 2★

Clinical trials in Portland: what's recruiting

The Portland area currently has 167 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Portland, the most active research areas are:

  • Cancer & Oncology16 studies
  • Heart & Vascular1 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Portland, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Portland

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Portland participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Portland?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Portland, ME?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Portland?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Portland.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Portland typically complete one or two studies per year.

Paid clinical trials near Portland

Other metros within reach

Manchester, NH89 Nashua, NH257 Boston, MA2,949 Worcester, MA270 New Bedford, MA514 Providence, RI551 Springfield, MA325 Norwich, CT121

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts