Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Worcester
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Worcester, MA

Studies commonly pay $75 to $4,500 per completed study

270 clinical trials are currently recruiting participants within 30 miles of Worcester. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

270studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Worcester right now

Top 25 of 270 recruiting studies, sorted by proximity — each links to its official registry page

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Obesity Phase 3 Interventional 600 participants sought
Clinical Res Collaborative — Cumberland, Rhode Island (28.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07503210)

Influences of Long-acting Reversible Contraceptives on Iron Status and Physiological Responses to Extreme Environments in Women

Contraception, Iron Deficiencies N/A Observational 33 participants sought
US Army Research Institute of Environmental Medicine — Natick, Massachusetts (23.5 mi) · Sponsor: United States Army Research Institute of Environmental Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06909695)

Promoting Improved Functioning Among People Experiencing Stressful Situations

Acute Stress Reaction N/A Interventional 450 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: University of North Carolina, Chapel Hill
See eligibility & contact on ClinicalTrials.gov (NCT06482567)

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine Phase 3 Interventional 200 participants sought
New England Regional Headache Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06616194)

Self-administered ONe-of-a Kind Approach to Epilepsy Therapy Through a Web-based Music Application

Epilepsy, Refractory Epilepsy N/A Interventional 24 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Dartmouth-Hitchcock Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06425029)

A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis

Systemic Sclerosis Phase 3 Interventional 92 participants sought
Local Institution - 0084 — Worcester, Massachusetts (0.6 mi) · Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
See eligibility & contact on ClinicalTrials.gov (NCT07335562)

Pelvic Vein Quantitative Flow Characterization Using 2D and 4D Flow MRI

May-Thurner Syndrome, Iliac Venous Compression N/A Interventional 15 participants sought
University of Massachusetts — Worcester, Massachusetts (0.6 mi) · Sponsor: Ningcheng Peter Li
See eligibility & contact on ClinicalTrials.gov (NCT06888024)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

Moderately to Severely Active Crohns Disease Phase 3 Interventional 425 participants sought
University of Massachusetts Memorial Medical Center — North Worcester, Massachusetts (3.2 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT06819891)

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Systemic Lupus Erythematosus, Lupus Nephritis Phase 1, Phase 2 Interventional 28 participants sought
UMass Memorial Hospital — Worcester, Massachusetts (0.6 mi) · Sponsor: Cabaletta Bio
See eligibility & contact on ClinicalTrials.gov (NCT06121297)

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma Phase 2 Interventional 80 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT02981628)

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 Phase 2 Interventional 474 participants sought
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional — Milford, Massachusetts (17.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632977)

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

Ovarian Neoplasms, Fallopian Tube Neoplasms Phase 3 Interventional 1,630 participants sought
University of Massachusetts Chan Medical School — Worcester, Massachusetts (0.6 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07213804)

Lupus Landmark Study: A Prospective Registry and Biorepository

Systemic Lupus Erythematosus (SLE), Lupus Nephritis N/A Observational 3,500 participants sought
University of Massachusetts Memorial Health — Worcester, Massachusetts (0.6 mi) · Sponsor: Lupus Research Alliance
See eligibility & contact on ClinicalTrials.gov (NCT05934149)

ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

Major Depressive Disorder (MDD), Depressive Disorder, Treatment-Resistant Phase 2 Interventional 153 participants sought
Vitalix Clinical, Inc. — Worcester, Massachusetts (0.6 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07284667)

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
Reliant Medical Group Inc — Worcester, Massachusetts (0.6 mi) · Sponsor: Amgen
See eligibility & contact on ClinicalTrials.gov (NCT05920356)

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

Intracranial Meningioma, Recurrent Meningioma Phase 2 Interventional 124 participants sought
UMass Memorial Medical Center - University Campus — Worcester, Massachusetts (0.6 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02523014)

A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

Acute Treatment of Migraine Phase 4 Interventional 400 participants sought
New England Regional Headache Center — Worcester, Massachusetts (0.6 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT07609914)

Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

Breast Cancer N/A Interventional 2,032 participants sought
Boston Breast Diagnostic Center — Wellesley Hills, Massachusetts (27.2 mi) · Sponsor: American College of Radiology
See eligibility & contact on ClinicalTrials.gov (NCT05625659)

Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne

Acne Phase 1, Phase 2 Interventional 800 participants sought
Kuchnir Dermatology & Dermatologic Surgery- Site Number : 8400096 — Marlborough, Massachusetts (14.1 mi) · Sponsor: Sanofi Pasteur, a Sanofi Company
See eligibility & contact on ClinicalTrials.gov (NCT06316297)
Google-rated

Top-rated research centers in Worcester

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Reliant Medical Group Research Department

640 Lincoln St, Worcester, MA 01605
(508) 595-2195

PracticePoint: Accelerating Medtech Innovation & Empowering Medskill Training

★ 5.0
Gateway Park II, 50 Prescott St, Worcester, MA 01605
(508) 831-4653

Meyers Health Care Institute

385 Grove St, Worcester, MA 01605
(508) 791-7392

Center For Outcomes Research

55 N Lake Ave, Worcester, MA 01655
(508) 856-1336

UMass Cancer Walk

55 N Lake Ave, Worcester, MA 01655
(508) 856-2589

Community Healthlink, Inc.

★ 2.5
72 Jaques Ave, Worcester, MA 01610
(508) 860-1000

Eunice Kennedy Shriver Center

55 N Lake Ave, Worcester, MA 01655
(774) 455-6562

Behavioral Healthcare Services

★ 3.3 (185 reviews)
435 Shrewsbury St, Worcester, MA 01604
(508) 753-5554
"I had a very disappointing experience with Sherrie Urena. I arrived on time for my scheduled appointment, but after waiting over 30 minutes without b…"
— Christina Garoulis, 1★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Worcester: what's recruiting

The Worcester area currently has 270 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Worcester, the most active research areas are:

  • Cancer & Oncology6 studies
  • Immune & Skin3 studies
  • Diabetes & Metabolism1 studies
  • Liver & Kidney1 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Worcester, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Worcester

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Worcester participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Are clinical trials in Worcester safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Worcester, MA?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
What is the difference between a research center and a hospital study in Worcester?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Worcester?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Worcester.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Worcester typically complete one or two studies per year.

Paid clinical trials near Worcester

Other metros within reach

Nashua, NH257 Providence, RI551 Boston, MA2,949 Springfield, MA325 Norwich, CT121 Manchester, NH89 Hartford, CT445 New Bedford, MA514

More of MA

Boston2,949 New Bedford514 Springfield325

New paid studies open every week

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