Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MA/Springfield
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Springfield, MA

Studies commonly pay $75 to $4,500 per completed study

325 clinical trials are currently recruiting participants within 30 miles of Springfield. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

325studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Springfield right now

Top 25 of 325 recruiting studies, sorted by proximity — each links to its official registry page

QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

HER2-positive Metastatic Breast Cancer N/A Observational 200 participants sought
Smilow Cancer Hospital at Saint Francis — Hartford, Connecticut (25.4 mi) · Sponsor: Abramson Cancer Center at Penn Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06551116)

Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

Prostate Cancer Phase 4 Interventional 700 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT05803941)

Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder

Problems Related to Social Environment N/A Interventional 318 participants sought
University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: NYU Langone Health
See eligibility & contact on ClinicalTrials.gov (NCT05675735)

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Multiple conditions Phase 2 Interventional 150 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05136196)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma Phase 3 Interventional 1,450 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04566328)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
Hartford HealthCare - Manchester — Manchester, Connecticut (23.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Endometrial Cancer, Endometrioid Adenocarcinoma N/A Observational 1,715 participants sought
Hartford Healthcare Cancer Institute @ Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Memorial Sloan Kettering Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT04291612)

Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program

Glycogen Storage Disease Type Ia N/A Observational 140 participants sought
University of Connecticut Health Center — Hartford, Connecticut (25.4 mi) · Sponsor: Ultragenyx Pharmaceutical Inc
See eligibility & contact on ClinicalTrials.gov (NCT06636383)

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer Phase 3 Interventional 4,300 participants sought
Research Site — Hartford, Connecticut (25.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05774951)

Pembrolizumab, Olaparib, and Temozolomide for People With Glioma

Glioma Phase 2 Interventional 57 participants sought
Hartford Healthcare Alliance (Data Collection Only) — Hartford, Connecticut (25.4 mi) · Sponsor: Memorial Sloan Kettering Cancer Center
See eligibility & contact on ClinicalTrials.gov (NCT05188508)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

Metastatic Malignant Neoplasm in the Lung, Metastatic Osteosarcoma Phase 3 Interventional 62 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT05235165)

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Recurrent B Acute Lymphoblastic Leukemia, Recurrent B Lymphoblastic Lymphoma Phase 2 Interventional 80 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT02981628)

Evaluation of Milk Polar Lipids in Dyslipidemic Adults With Abdominal Obesity

Dyslipidemias, Obesity EARLY/Phase 1 Interventional 130 participants sought
University of Connecticut — Storrs, Connecticut (25.9 mi) · Sponsor: University of Connecticut
See eligibility & contact on ClinicalTrials.gov (NCT05700916)

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8 Phase 2 Interventional 474 participants sought
Baystate Medical Center — Springfield, Massachusetts (2.8 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT06632977)

Genomically Profiling, Collecting, Archiving and Distributing Hematologic Malignancy Specimens

Leukemia, Myelodysplastic Syndromes N/A Observational 300 participants sought
Connecticut Children's Medical Center — Hartford, Connecticut (25.4 mi) · Sponsor: Dana-Farber Cancer Institute
See eligibility & contact on ClinicalTrials.gov (NCT04968834)

Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

Schizophrenia Spectrum and Other Psychotic Disorders, Schizophrenia N/A Observational 320 participants sought
Hartford Hospital — Hartford, Connecticut (25.4 mi) · Sponsor: Beth Israel Deaconess Medical Center
See eligibility & contact on ClinicalTrials.gov (NCT06740383)
Google-rated

Top-rated research centers in Springfield

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Sisu Clincal Research

★ 3.5
95 Frank B Murray St, Springfield, MA 01103
(413) 305-1142
"I called and talked to a very nice Spanish woman. She answered all my questions was very direct very responsive. I’m trying to do the depression and …"
— Nicole Koske, 5★

Baystate Health Clinical Trials Unit

★ 5.0
80 Wason Ave, Springfield, MA 01107
(413) 794-6690

Elixia

★ 5.0
95 Frank B Murray St, Springfield, MA 01103
"Super friendly, had a good experience"
— Nick Bean, 5★

Colaccino Center For Health Sciences

★ 5.0
Springfield, MA 01109

Clinical Research Management Group

★ 5.0
1408 Main St, Agawam, MA 01001
(413) 821-0022

Pioneer Valley Life Sciences

3601 Main St, Springfield, MA 01107
(413) 794-0653

CT Clinical Research

160 West St Ste 1A, Cromwell, CT 06416
(860) 632-0144

Pioneer Behavioral Health

★ 5.0 (135 reviews)
175 Dwight Rd, Longmeadow, MA 01106
(888) 617-3070
"I cannot say enough good things about Pioneer Behavioral Health and the incredible team that helped me when I needed it most. When I first started th…"
— Nick, 5★

Clinical Trials of New England

1234 Hyde Park Ave #205, Hyde Park, MA 02136

Clinical trials in Springfield: what's recruiting

The Springfield area currently has 325 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Springfield, the most active research areas are:

  • Cancer & Oncology14 studies
  • Brain & Mental Health2 studies
  • Diabetes & Metabolism2 studies
  • Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Springfield, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Springfield

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Springfield participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Springfield pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Springfield?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
What is the difference between a research center and a hospital study in Springfield?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Springfield?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Springfield.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Springfield typically complete one or two studies per year.

Paid clinical trials near Springfield

Other metros within reach

Hartford, CT445 Norwich, CT121 Waterbury, CT1,146 Worcester, MA270 New Haven, CT1,187 Bridgeport, CT1,460 Providence, RI551 Danbury, CT1,164

More of MA

Boston2,949 New Bedford514 Worcester270

New paid studies open every week

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