Do I need to be sick to join a clinical trial in Spring Hill?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

How do I join a study in Spring Hill, FL?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

What is the difference between a research center and a hospital study in Spring Hill?

Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

How often do new paid studies open in Spring Hill?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Spring Hill.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Spring Hill typically complete one or two studies per year.

Paid Clinical Trials Spring Hill, FL — 116 Studies Recruiting (Jul 2026)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought

Retina Specialists of Tampa — Wesley Chapel, Florida (20.6 mi) · Sponsor: Astellas Pharma Global Development, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06779773)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04671667)

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Locally Advanced Lung Non-Small Cell Carcinoma, Metastatic Lung Non-Small Cell Carcinoma Phase 1, Phase 2 Interventional 37 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT07012031)

Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

Bacterial Conjunctivitis Phase 3 Interventional 400 participants sought

Baxis Site 27 — Lutz, Florida (23.1 mi) · Sponsor: Baxis Pharmaceuticals, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06911424)

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

Episodic Migraine Phase 3 Interventional 450 participants sought

Asclepes Research Centers - Spring Hill /ID# 248525 — Spring Hill, Florida (0.3 mi) · Sponsor: AbbVie

See eligibility & contact on ClinicalTrials.gov (NCT05711394)

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

Type 1 Diabetes Mellitus With Hypoglycemia Phase 2 Interventional 186 participants sought

Suncoast Clinical Research — New Port Richey, Florida (19.9 mi) · Sponsor: Zucara Therapeutics Inc.

See eligibility & contact on ClinicalTrials.gov (NCT05762107)

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

Cardiovascular, Metabolic Disease Phase 1 Interventional 90 participants sought

Research Site 19 — High Point, Florida (4.6 mi) · Sponsor: CRISPR Therapeutics AG

See eligibility & contact on ClinicalTrials.gov (NCT07491172)

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma, Follicular Lymphoma With Unusual Cytological Features Phase 3 Interventional 600 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06337318)

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

Type 2 Diabetes, Cortisol Excess Phase 2 Interventional 1,500 participants sought

Suncoast Clinical Research, Inc — New Port Richey, Florida (19.9 mi) · Sponsor: Sparrow Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT07296484)

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

Non-muscle Invasive Bladder Cancer Phase 1 Interventional 294 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT07206225)

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPD, Smoking N/A Interventional 290 participants sought

Advanced Research Institute, Inc — New Port Richey, Florida (19.9 mi) · Sponsor: Philip Morris Products S.A.

See eligibility & contact on ClinicalTrials.gov (NCT07108166)

A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

Psoriatic Arthritis, Axial Spondyloarthritis Phase 1 Interventional 392 participants sought

Pa0019 133 — Zephyrhills, Florida (27.2 mi) · Sponsor: UCB Biopharma SRL

See eligibility & contact on ClinicalTrials.gov (NCT07290036)

A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

Non-alcoholic Fatty Liver Disease Phase 3 Interventional 1,200 participants sought

GSK Investigational Site — Inverness, Florida (27.4 mi) · Sponsor: GlaxoSmithKline

See eligibility & contact on ClinicalTrials.gov (NCT07221227)

Secukinumab Open Label Roll-over Extension Protocol

Autoimmunity, Inflammation Phase 4 Interventional 1,000 participants sought

FL Medical Clinic Orlando Health — Zephyrhills, Florida (27.2 mi) · Sponsor: Novartis Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT04638647)

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

NASH With Fibrosis, MASH With Fibrosis Phase 3 Interventional 1,650 participants sought

Akero Clinical Study Site — New Port Richey, Florida (19.9 mi) · Sponsor: Akero Therapeutics, Inc

See eligibility & contact on ClinicalTrials.gov (NCT06215716)

Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM

Epiretinal Membrane N/A Interventional 400 participants sought

SEASHORE RETINA LLC DBA Retina Specialists of Tampa — Wesley Chapel, Florida (20.6 mi) · Sponsor: Jaeb Center for Health Research

See eligibility & contact on ClinicalTrials.gov (NCT05145491)

A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥6 Months to <18 Years of Age With Prurigo Nodularis

Prurigo Nodularis Phase 3 Interventional 18 participants sought

SunCoast Skin Solutions - Lutz- Site Number : 8400008 — Lutz, Florida (23.1 mi) · Sponsor: Sanofi

See eligibility & contact on ClinicalTrials.gov (NCT06293053)

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Metastatic Lung Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain Phase 3 Interventional 200 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT04804644)

Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC

Locally Advanced Pancreatic Cancer Phase 3 Interventional 190 participants sought

ASCLEPES Research Centers — Weeki Wachee, Florida (3.6 mi) · Sponsor: RenovoRx

See eligibility & contact on ClinicalTrials.gov (NCT03257033)

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Previously Treated Non-Small Cell Lung Cancer Phase 2, Phase 3 Interventional 10,000 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03851445)

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

Advanced Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8 Phase 3 Interventional 304 participants sought

Moffitt Cancer Center at Wesley Chapel — Wesley Chapel, Florida (20.6 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT06096844)

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Osteoarthritis, Knee, Diabetic Neuropathic Pain Phase 2 Interventional 10,000 participants sought

Suncoast Clinical Research, Inc. — New Port Richey, Florida (19.9 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT05986292)

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

Primary Biliary Cholangitis, PBC Phase 2 Interventional 260 participants sought

Advanced Research Institute, Inc — New Port Richey, Florida (19.9 mi) · Sponsor: Mirum Pharmaceuticals, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT05050136)

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

Alzheimer Disease, Dementia Phase 3 Interventional 550 participants sought

Suncoast Clinical Research, Inc. — New Port Richey, Florida (19.9 mi) · Sponsor: Eli Lilly and Company

See eligibility & contact on ClinicalTrials.gov (NCT07602582)

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

Graves Disease Phase 1 Interventional 100 participants sought

Site # 1109 — Wesley Chapel, Florida (20.6 mi) · Sponsor: Merida Biosciences

See eligibility & contact on ClinicalTrials.gov (NCT07305818)

Paid Clinical Trials in Spring Hill, FL

Studies recruiting near Spring Hill right now

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Efficacy of Fusidic Acid 1% in the Treatment of Bacterial Conjunctivitis

A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D)

A Study to Learn About the Study Medicine PF-08052667 in People With Bladder Cancer

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults

A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

Secukinumab Open Label Roll-over Extension Protocol

A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM

A Study to Investigate the Pharmacokinetics and Safety of Dupilumab in Participants ≥6 Months to <18 Years of Age With Prurigo Nodularis

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Biliary Cholangitis

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

NEXUS Study: A Study to Test Single and Multiple Doses of MER511 Given to Adults With Graves' Disease

Top-rated research centers in Spring Hill

Access Research Institute

Florida Cancer Specialists & Research Institute

Advanced Research Institute, Inc.

Clinical Research of West Florida, Inc - Tampa

Florida Cancer Specialists & Research Institute

CenExel Tampa FL

Suncoast Clinical Research

Florida Cancer Specialists & Research Institute

Clinical Research of West Florida , Inc - Clearwater

Clinical trials in Spring Hill: what's recruiting

How to enroll in a paid study in Spring Hill

Frequently asked questions

Paid clinical trials near Spring Hill

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