Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/FL/Orlando
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Orlando, FL

Studies commonly pay $75 to $4,500 per completed study

934 clinical trials are currently recruiting participants within 30 miles of Orlando. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

934studies recruiting
4+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Orlando right now

Top 25 of 934 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
AdventHealth — Altamonte Springs, Florida (12.8 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Obesity Phase 3 Interventional 600 participants sought
Florida Inst For Clin Res LLC — Orlando, Florida (4.9 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07503210)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Orlando, Florida (4.9 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis Phase 2 Interventional 180 participants sought
Neurology Associates, P. A. — Maitland, Florida (10.5 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07029581)

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Solid Tumor Cancer, Locally Advanced Phase 1, Phase 2 Interventional 480 participants sought
Avenzo Therapeutics Recruiting Site — Orlando, Florida (4.9 mi) · Sponsor: Avenzo Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07038343)

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

Uncontrolled Hypertension Phase 2 Interventional 280 participants sought
Retension Clinical Site — Orlando, Florida (4.9 mi) · Sponsor: Retension Pharmaceuticals. Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07142356)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Florida Eye Clinic — Altamonte Springs, Florida (12.8 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Ulcerative Colitis, Crohn's Disease Phase 3 Interventional 240 participants sought
I.H.S Health LLC-Kissimmee-445 W Oak St — Kissimmee, Florida (12.9 mi) · Sponsor: Takeda
See eligibility & contact on ClinicalTrials.gov (NCT05442567)

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

Atherosclerotic Cardiovascular Disease (ASCVD) Phase 3 Interventional 340 participants sought
FC Site Partners Miami — Winter Park, Florida (8.5 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06813911)

A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease

Sjögren, Sjogren Disease Phase 1 Interventional 36 participants sought
Cullinan Investigative Site — Orlando, Florida (4.9 mi) · Sponsor: Cullinan Therapeutics Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07041099)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
Florida Cancer Specialists — Orlando, Florida (4.9 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Diabetes Mellitus, Type 2 Phase 2 Interventional 270 participants sought
West Orange Endocrinology — Ocoee, Florida (14.1 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07415954)

Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Who Are Not Achieving Glycemic Targets

Type 2 Diabetes Phase 2 Interventional 60 participants sought
Clinical Site Partners, LLC dba Flourish Research — Winter Park, Florida (8.5 mi) · Sponsor: Biomea Fusion Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07502495)

Effect of Resveratrol Supplementation on Exercise Performance and Recovery

Effect of Resveratrol on Performance and Recovery N/A Interventional 20 participants sought
University of Central Florida EPIC Lab — Orlando, Florida (4.9 mi) · Sponsor: University of Central Florida
See eligibility & contact on ClinicalTrials.gov (NCT06723119)

A Study to Assess NAV-240 in Adult Participants With Hidradenitis Suppurativa

Hidradenitis Suppurativa (HS) Phase 2 Interventional 150 participants sought
Accel Research Sites Network — Maitland, Florida (10.5 mi) · Sponsor: Navigator Medicines, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07384975)

A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems

Healthy, Hepatic Impairment Phase 1 Interventional 32 participants sought
Orlando Clinical Research Center — Orlando, Florida (4.9 mi) · Sponsor: Boehringer Ingelheim
See eligibility & contact on ClinicalTrials.gov (NCT07023354)

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

Polymyositis, Dermatomyositis Phase 3 Interventional 240 participants sought
Research Site — Orlando, Florida (4.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT06455449)

A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

Ulcerative Colitis, Ulcerative Colitis Chronic Phase 2 Interventional 140 participants sought
Orlando Health Digestive Health Institute — Orlando, Florida (4.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT06598943)

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Advanced/Metastatic Solid Tumors, Colorectal Cancer Phase 1, Phase 2 Interventional 523 participants sought
Sarah Cannon Research Institute (Lake Nona) — Orlando, Florida (4.9 mi) · Sponsor: Merus B.V.
See eligibility & contact on ClinicalTrials.gov (NCT03526835)

Feasibility and Acceptability of a Pediatric Referral to Summer Day Camps to Treat Obesity in Children From Low-Income Households

Obesity & Overweight N/A Interventional 80 participants sought
University of Central Florida — Orlando, Florida (4.9 mi) · Sponsor: University of Central Florida
See eligibility & contact on ClinicalTrials.gov (NCT07464015)

A Post-Authorisation Safety Study (PASS) of Patients Treated With Lonapegsomatropin

Growth Hormone Deficiency N/A Observational 500 participants sought
Ascendis Investigational Site — Orlando, Florida (4.9 mi) · Sponsor: Ascendis Pharma Endocrinology Division A/S
See eligibility & contact on ClinicalTrials.gov (NCT05775523)
Google-rated

Top-rated research centers in Orlando

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Orlando Clinical Research Center

★ 4.6
5055 S Orange Ave, Orlando, FL 32809
(407) 240-7878
"Friendly informative doctors and nurses..."
— Jeffrey Kallas, 5★

Cli research

3885 Oakwater Cir, Orlando, FL 32806

Discovery Clinical Trials

★ 5.0
2863 Delaney St, Orlando, FL 32806
(321) 445-8001

Florida Institute for Clinical Research

★ 4.8
10967 Lake Underhill Rd Ste 117, Orlando, FL 32825
(407) 658-0966
"Was involved in a study there for 2 years. Staff is very professional , friendly, and curtios. Especially Marisa, Geo, and Dr Cruz."
— Alan Porreca, 4★

Clinical trials in Orlando: what's recruiting

The Orlando area currently has 934 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Orlando, the most active research areas are:

  • Cancer & Oncology4 studies
  • Diabetes & Metabolism4 studies
  • Immune & Skin4 studies
  • Heart & Vascular2 studies
  • Liver & Kidney1 studies

Every listing shows the study phase, the recruiting site and its distance from Orlando, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Orlando

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Orlando participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Orlando?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
How do I join a study in Orlando, FL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Orlando?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Orlando typically complete one or two studies per year.

Paid clinical trials near Orlando

Other metros within reach

Kissimmee, FL920 Deltona, FL948 Winter Haven, FL155 Leesburg, FL135 Lakeland, FL181 Palm Bay, FL60 Ocala, FL124 Spring Hill, FL116

More of FL

Fort Lauderdale1,989 Pembroke Pines1,985 Hollywood1,985 Hialeah1,939 Miami1,914 St. Petersburg1,328 Tampa1,310 Deltona948 Kissimmee920 Jacksonville893 Gainesville539

New paid studies open every week

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