Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Santa Ana
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Ana, CA

Studies commonly pay $75 to $4,500 per completed study

1,911 clinical trials are currently recruiting participants within 30 miles of Santa Ana. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,911studies recruiting
9+research centers nearby
4condition categories
Live from the NIH registry

Studies recruiting near Santa Ana right now

Top 25 of 1,911 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
City of Hope National Medical Center — Duarte, California (28.4 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Orange County Retina Med Group — Santa Ana, California (1.0 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Santa Ana, California (1.0 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications

Glaucoma, Ocular Surface Disease N/A Observational 75 participants sought
Doheny Eye Center UCLA — Fountain Valley, California (4.5 mi) · Sponsor: University of California, Los Angeles
See eligibility & contact on ClinicalTrials.gov (NCT04354545)

Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)

Colorectal Cancer Metastatic Phase 2 Interventional 20 participants sought
Hoag Memorial Hospital Presbyterian — Newport Beach, California (8.6 mi) · Sponsor: Buzzard Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06634875)

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis Phase 2 Interventional 180 participants sought
ATP Clinical Research Inc. — Irvine, California (5.7 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07029581)

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

Lymphoma, B-Cell, Lymphoma, Non-Hodgkin (NHL) Phase 1 Interventional 106 participants sought
City of Hope — Duarte, California (28.4 mi) · Sponsor: Umoja Biopharma
See eligibility & contact on ClinicalTrials.gov (NCT06528301)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Providence Medical Foundation ( Site 0141) — Fullerton, California (9.6 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) Phase 1 Interventional 248 participants sought
University of California Irvine — Orange, California (3.9 mi) · Sponsor: Nurix Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04830137)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California (3.9 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Phase 1 Interventional 36 participants sought
City of Hope Medical Center — Duarte, California (28.4 mi) · Sponsor: PeproMene Bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05370430)

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

Systemic Lupus Erythematosus Phase 3 Interventional 550 participants sought
Advanced Medical Research — La Palma, California (12.1 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06133972)

Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

Viral Pneumonia Phase 2 Interventional 550 participants sought
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center — Torrance, California (27.2 mi) · Sponsor: Synairgen Research Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06999603)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
University of California Irvine Medical Center — Orange, California (3.9 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

Adjuvant Sacituzumab Govitecan and Nivolumab in Muscle-Invasive Urothelial Carcinoma at High-Risk Recurrence

Urothelial Carcinoma, Muscle-invasive Bladder Cancer Phase 2 Interventional 23 participants sought
Chao Family Comprehensive Cancer Center, University of California, Irvine — Orange, California (3.9 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06682728)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
Providence Medical Foundation — Anaheim, California (7.1 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

Opioid Use Disorder N/A Interventional 3,492 participants sought
University of California Irvine Emergency Department — Irvine, California (5.7 mi) · Sponsor: University of California, Davis
See eligibility & contact on ClinicalTrials.gov (NCT07024498)

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Transitional Cell Cancer of Renal Pelvis and Ureter Phase 3 Interventional 100 participants sought
University of California - Irvine Medical Center — Irvine, California (5.7 mi) · Sponsor: Steba Biotech S.A.
See eligibility & contact on ClinicalTrials.gov (NCT04620239)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange, California (3.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)
Google-rated

Top-rated research centers in Santa Ana

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Ark Clinical Research

★ 5.0
11160 Warner Ave Ste 311, Fountain Valley, CA 92708
(714) 988-2021
"I love this clinic, everyone that works there is really pleasant, and they make everyone feel comfortable and welcome. I would recommend to any and e…"
— Megan Fillmore, 5★

Sierra Clinical Trials

2010 E 1st St, Santa Ana, CA 92705
(714) 647-1200

NRC Research Institute

★ 4.7
1010 W Chapman Ave, Orange, CA 92868
(714) 289-1100
"Great women nurses and what not fun place to get paid amazing place helped me restart my life thank you guys here'sy adres 9460 carnation Westminster…"
— Hibrahim Lozano, 5★

Velocity Clinical Research

★ 5.0
2621 S Bristol St Ste 303, Santa Ana, CA 92704
(714) 599-8711
"I would like to participate in these clinical studies. I participated in three studies in Mexico at the CECYPE laboratory, and I would like to partic…"
— simon, 5★

Syrentis Clinical Research

★ 4.8
1401 N Tustin Ave #130, Santa Ana, CA 92705
(714) 475-0556
"The Docs and staff at Syrentis Clinical Research are always courteous and professional. They provide a caring environment and communicate all aspect…"
— Glenn Christensen, 5★

Knowledge Research Center

★ 5.0
1010 W La Veta Ave #575, Orange, CA 92868
(657) 247-0087

SDS Clinical Trials

★ 4.8
1535 17th St Ste 101, Santa Ana, CA 92705
(714) 834-1565
"Wonderful caring doctors and staff! They treat their volunteers very well. I like that there are not a lot of other people at the facility when I'm t…"
— Colleen Carmichael, 5★

Wolverine Clinical Trials

★ 5.0
2107 N Broadway Ste 306, Santa Ana, CA 92706
(714) 617-2426
"I had a great experience at this office. Everyone was professional and caring."
— Delia Aponte, 5★

Irvine Clinical Research

★ 4.6
2515 McCabe Way #350, Irvine, CA 92614
(949) 753-1663
"Really positive experience overall. The staff and coordinators are all so caring and professional throughout the entire process. You can tell they ge…"
— Kevin Tan, 5★

Clinical trials in Santa Ana: what's recruiting

The Santa Ana area currently has 1,911 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Ana, the most active research areas are:

  • Cancer & Oncology13 studies
  • Heart & Vascular3 studies
  • Liver & Kidney3 studies
  • Immune & Skin1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Ana, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Ana

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Ana participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Santa Ana?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Santa Ana safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
What is the difference between a research center and a hospital study in Santa Ana?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Santa Ana?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Ana.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Ana typically complete one or two studies per year.

Paid clinical trials near Santa Ana

Other metros within reach

Garden Grove, CA3,152 Anaheim, CA3,155 Irvine, CA1,507 Huntington Beach, CA2,841 Fullerton, CA3,223 Mission Viejo, CA1,371 Long Beach, CA3,341 Corona, CA1,557

More of CA

Long Beach3,341 Torrance3,236 Fullerton3,223 Anaheim3,155 Garden Grove3,152 Pomona3,119 Glendale2,957 Los Angeles2,943 Huntington Beach2,841 Santa Clarita2,395 Hayward2,256 Oakland2,249

New paid studies open every week

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