Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/CA/Mission Viejo
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Mission Viejo, CA

Studies commonly pay $75 to $4,500 per completed study

1,371 clinical trials are currently recruiting participants within 30 miles of Mission Viejo. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,371studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near Mission Viejo right now

Top 25 of 1,371 recruiting studies, sorted by proximity — each links to its official registry page

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Orange County Retina Med Group — Santa Ana, California (15.4 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Santa Ana, California (15.4 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications

Glaucoma, Ocular Surface Disease N/A Observational 75 participants sought
Doheny Eye Center UCLA — Fountain Valley, California (18.5 mi) · Sponsor: University of California, Los Angeles
See eligibility & contact on ClinicalTrials.gov (NCT04354545)

Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)

Colorectal Cancer Metastatic Phase 2 Interventional 20 participants sought
Hoag Memorial Hospital Presbyterian — Newport Beach, California (15.8 mi) · Sponsor: Buzzard Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06634875)

Phase 2, Efficacy and Safety Study of ACP-204 in Lewy Body Dementia Psychosis

Lewy Body Dementia Psychosis Phase 2 Interventional 180 participants sought
ATP Clinical Research Inc. — Irvine, California (10.5 mi) · Sponsor: ACADIA Pharmaceuticals Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07029581)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Providence Medical Foundation ( Site 0141) — Fullerton, California (23.8 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) Phase 1 Interventional 248 participants sought
University of California Irvine — Orange, California (16.8 mi) · Sponsor: Nurix Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04830137)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California (10.5 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

Systemic Lupus Erythematosus Phase 3 Interventional 550 participants sought
Advanced Medical Research — La Palma, California (27.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06133972)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Harvard Eye Associates — Laguna Hills, California (3.3 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

Adjuvant Sacituzumab Govitecan and Nivolumab in Muscle-Invasive Urothelial Carcinoma at High-Risk Recurrence

Urothelial Carcinoma, Muscle-invasive Bladder Cancer Phase 2 Interventional 23 participants sought
Chao Family Comprehensive Cancer Center, University of California, Irvine — Orange, California (16.8 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06682728)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
Providence Medical Foundation — Anaheim, California (21.6 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

Opioid Use Disorder N/A Interventional 3,492 participants sought
University of California Irvine Emergency Department — Irvine, California (10.5 mi) · Sponsor: University of California, Davis
See eligibility & contact on ClinicalTrials.gov (NCT07024498)

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Transitional Cell Cancer of Renal Pelvis and Ureter Phase 3 Interventional 100 participants sought
University of California - Irvine Medical Center — Irvine, California (10.5 mi) · Sponsor: Steba Biotech S.A.
See eligibility & contact on ClinicalTrials.gov (NCT04620239)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California (10.5 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Diabetes Mellitus, Type 2 Phase 2 Interventional 270 participants sought
Pacific Clinical Studies — Los Alamitos, California (27.5 mi) · Sponsor: Novo Nordisk A/S
See eligibility & contact on ClinicalTrials.gov (NCT07415954)

Comparison of Uncomplicated Candidemia Therapy Duration in Children

Invasive Candidiasis N/A Interventional 420 participants sought
Children's Hospital of Orange County — Orange, California (16.8 mi) · Sponsor: Arkansas Children's Hospital Research Institute
See eligibility & contact on ClinicalTrials.gov (NCT05763251)

PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis

Gastrointestinal Cancer, Peritoneal Carcinomatosis EARLY/Phase 1 Interventional 10 participants sought
Chao Family Comprehensive Cancer Center, University of California, Irvine — Orange, California (16.8 mi) · Sponsor: University of California, Irvine
See eligibility & contact on ClinicalTrials.gov (NCT06511037)

A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT

Port-wine Birthmarks, Port-Wine Stain Phase 2 Interventional 84 participants sought
UCI Health Beckman Laser Institute & Medical Clinic — Irvine, California (10.5 mi) · Sponsor: Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT05171894)
Google-rated

Top-rated research centers in Mission Viejo

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Orange County Research Center

★ 4.5
25381 Commercentre Dr, Lake Forest, CA 92630
(714) 550-9990
"The care and kindness I received at this medical facility truly deserve to be recognized. From the very first visit, I felt welcomed and genuinely ca…"
— Ines L. Trejos, 5★

Alliance Research Centers

★ 2.0
24012 Calle De La Plata Ste 230, Laguna Hills, CA 92653
(949) 680-3490
"Alliance illegally misrepresents hidden glucose study as only beverage study to underpay 66% plus. Scam, rip off alert! Beverage weight loss study th…"
— Dai Truong, 1★

Avance Clinical Trials

27020 Alicia Pkwy G, Laguna Niguel, CA 92677
(949) 844-0442

Amnova Clinical Research, LLC

★ 5.0
4902 Irvine Center Dr Ste 104, Irvine, CA 92604
(949) 777-5818
"Couldn’t be happier with the care and treatment for my son. Everything from blood draws to communication outside of business hours made me feel at ea…"
— Tara Popov, 5★

Irvine Research Center

Irvine, CA

Irvine Clinical Research

★ 4.6
2515 McCabe Way #350, Irvine, CA 92614
(949) 753-1663
"Really positive experience overall. The staff and coordinators are all so caring and professional throughout the entire process. You can tell they ge…"
— Kevin Tan, 5★

NRC Research Institute

★ 4.7
1010 W Chapman Ave, Orange, CA 92868
(714) 289-1100
"Great women nurses and what not fun place to get paid amazing place helped me restart my life thank you guys here'sy adres 9460 carnation Westminster…"
— Hibrahim Lozano, 5★

ClinDatrix, Inc.

1 Ada Ste 250, Irvine, CA 92618
(949) 428-6600

Kinetic Clinical Research

★ 5.0
215 N State College Blvd A, Anaheim, CA 92806
(657) 230-7120

Clinical trials in Mission Viejo: what's recruiting

The Mission Viejo area currently has 1,371 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Mission Viejo, the most active research areas are:

  • Cancer & Oncology11 studies
  • Heart & Vascular2 studies
  • Liver & Kidney2 studies
  • Immune & Skin1 studies
  • Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Mission Viejo, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Mission Viejo

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Mission Viejo participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Mission Viejo pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in Mission Viejo?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Mission Viejo safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Mission Viejo?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Mission Viejo.

Paid clinical trials near Mission Viejo

Other metros within reach

Irvine, CA1,507 Santa Ana, CA1,911 Corona, CA1,557 Anaheim, CA3,155 Garden Grove, CA3,152 Huntington Beach, CA2,841 Fullerton, CA3,223 Riverside, CA934

More of CA

Long Beach3,341 Torrance3,236 Fullerton3,223 Anaheim3,155 Garden Grove3,152 Pomona3,119 Glendale2,957 Los Angeles2,943 Huntington Beach2,841 Santa Clarita2,395 Hayward2,256 Oakland2,249

New paid studies open every week

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