How much do paid clinical trials in Santa Clarita pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Are clinical trials in Santa Clarita safe?

Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.

How do I join a study in Santa Clarita, CA?

Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.

What is the difference between a research center and a hospital study in Santa Clarita?

Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.

How often do new paid studies open in Santa Clarita?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Clarita.

Paid Clinical Trials Santa Clarita, CA — 2395 Studies Recruiting (Jul 2026)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought

Beverly Hills Cancer Center — Beverly Hills, California (24.4 mi) · Sponsor: Relay Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought

California Eye Specialists Medical group Inc. — Pasadena, California (27.4 mi) · Sponsor: Genentech, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Solid Tumor, Non-Small-Cell Lung Cancer Phase 1 Interventional 364 participants sought

UCLA Santa Monica Hematology Oncology — Santa Monica, California (27.5 mi) · Sponsor: Astellas Pharma Inc

See eligibility & contact on ClinicalTrials.gov (NCT07094204)

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

Amyotrophic Lateral Sclerosis Phase 3 Interventional 495 participants sought

University of Southern California — Los Angeles, California (29.1 mi) · Sponsor: AB Science

See eligibility & contact on ClinicalTrials.gov (NCT03127267)

Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)

Colorectal Cancer Metastatic Phase 2 Interventional 20 participants sought

USC/Norris Cancer Center — Los Angeles, California (29.1 mi) · Sponsor: Buzzard Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT06634875)

Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2 Interventional 21 participants sought

UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California (29.1 mi) · Sponsor: Jonsson Comprehensive Cancer Center

See eligibility & contact on ClinicalTrials.gov (NCT05775471)

Food is Medicine Prospective Study

Wounds and Injuries N/A Observational 75 participants sought

Cedars-Sinai Medical Center — Los Angeles, California (29.1 mi) · Sponsor: Cedars-Sinai Medical Center

See eligibility & contact on ClinicalTrials.gov (NCT07169448)

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Solid Tumor Cancer, Locally Advanced Phase 1, Phase 2 Interventional 480 participants sought

Avenzo Therapeutics Recruiting Site — Los Angeles, California (29.1 mi) · Sponsor: Avenzo Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07038343)

A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Angiokeratomas (LOTU)

Angiokeratomas Phase 2 Interventional 15 participants sought

Unified Health — Sherman Oaks, California (18.6 mi) · Sponsor: Palvella Therapeutics, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07552077)

Zenith® Fenestrated+ Clinical Study

Aortic Aneurysm, Abdominal, Juxtarenal Aortic Aneurysm N/A Interventional 105 participants sought

University of Southern California — Los Angeles, California (29.1 mi) · Sponsor: Cook Research Incorporated

See eligibility & contact on ClinicalTrials.gov (NCT04875429)

Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma

Glioblastoma, Recurrent Glioblastoma N/A Interventional 50 participants sought

UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California (29.1 mi) · Sponsor: Jonsson Comprehensive Cancer Center

See eligibility & contact on ClinicalTrials.gov (NCT06090903)

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

Systemic Lupus Erythematosus Phase 3 Interventional 550 participants sought

Providence Medical Center — Burbank, California (19.5 mi) · Sponsor: Novartis Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT06133972)

A Study of Dotinurad Versus Allopurinol in Participants With Gout

Gout Phase 3 Interventional 500 participants sought

Amicis Research Center - Balboa — Northridge, California (13.3 mi) · Sponsor: Crystalys Therapeutics

See eligibility & contact on ClinicalTrials.gov (NCT07089875)

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

Uncontrolled Hypertension Phase 2 Interventional 280 participants sought

Retension Clinical Site — West Hills, California (17.4 mi) · Sponsor: Retension Pharmaceuticals. Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07142356)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought

The Retina Partners — Encino, California (17.9 mi) · Sponsor: Astellas Pharma Global Development, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT06779773)

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Ulcerative Colitis, Crohn's Disease Phase 3 Interventional 240 participants sought

Cedars Sinai Medical Center - 127 San Vicente Blvd — Los Angeles, California (29.1 mi) · Sponsor: Takeda

See eligibility & contact on ClinicalTrials.gov (NCT05442567)

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

Atherosclerotic Cardiovascular Disease (ASCVD) Phase 3 Interventional 340 participants sought

Interv Cardiology Med Grp — West Hills, California (17.4 mi) · Sponsor: Novartis Pharmaceuticals

See eligibility & contact on ClinicalTrials.gov (NCT06813911)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought

UCLA Department of Medicine - Hematology & Oncology — Santa Monica, California (27.5 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Determining the Role of Social Reward Learning in Social Anhedonia

Psychosis N/A Interventional 152 participants sought

University of California Los Angeles — Los Angeles, California (29.1 mi) · Sponsor: University of Alabama at Birmingham

See eligibility & contact on ClinicalTrials.gov (NCT05617898)

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Transitional Cell Cancer of Renal Pelvis and Ureter Phase 3 Interventional 100 participants sought

Keck School of Medicine at USC Medical Center — Los Angeles, California (29.1 mi) · Sponsor: Steba Biotech S.A.

See eligibility & contact on ClinicalTrials.gov (NCT04620239)

Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents

Congenital Heart Disease N/A Interventional 40 participants sought

Children's Hospital Los Angeles — Los Angeles, California (29.1 mi) · Sponsor: Children's Hospital Los Angeles

See eligibility & contact on ClinicalTrials.gov (NCT07023367)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought

Kaiser Permanente Los Angeles Medical Center — Los Angeles, California (29.1 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04671667)

A Randomized, Triple-blind, Placebo-controlled Study to Evaluate the Effects of a Supplement on Nutrient Gaps and Gut Health Among Individuals Utilizing GLP-1 RAs

Nutrition Intake, Nutrition Status N/A Interventional 120 participants sought

Citruslabs — Santa Monica, California (27.5 mi) · Sponsor: Athletic Greens International

See eligibility & contact on ClinicalTrials.gov (NCT07437911)

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

Knee Cartilage Defects Phase 3 Interventional 300 participants sought

Source Healthcare — Santa Monica, California (27.5 mi) · Sponsor: Medipost, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT07339111)

Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck)

Endometriosis N/A Observational 1,200 participants sought

Velvet Clinical Research — Burbank, California (19.5 mi) · Sponsor: Aspira Women's Health

See eligibility & contact on ClinicalTrials.gov (NCT05245695)

Paid Clinical Trials in Santa Clarita, CA

Studies recruiting near Santa Clarita right now

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

Isunakinra Alone and in Combination With Pembrolizumab in Patients With Colorectal Cancer (MSS)

Pembrolizumab and Enfortumab Vedotin With Pembrolizumab Prior to and After Radical Nephroureterectomy for High-Risk Upper Tract Urothelial Cancer

Food is Medicine Prospective Study

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

A Phase 2, Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 (Sirolimus) Topical Gel 3.9% in the Treatment of Angiokeratomas (LOTU)

Zenith® Fenestrated+ Clinical Study

Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

A Study of Dotinurad Versus Allopurinol in Participants With Gout

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Determining the Role of Social Reward Learning in Social Anhedonia

ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Study

Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

A Randomized, Triple-blind, Placebo-controlled Study to Evaluate the Effects of a Supplement on Nutrient Gaps and Gut Health Among Individuals Utilizing GLP-1 RAs

Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis

Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck)

Top-rated research centers in Santa Clarita

Clearview Medical Research

Flourish Research - Los Angeles (Northridge)

Clinical Research of California

Alliance Research Institute(Roscoe Blvd)

Valiance Clinical Research Northridge

Clinical Research Center Centro De Estudios Clinicos

Alliance Clinical Canoga Park

Asclepes Research

Northridge Clinical Trials

Clinical trials in Santa Clarita: what's recruiting

How to enroll in a paid study in Santa Clarita

Frequently asked questions

Paid clinical trials near Santa Clarita

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New paid studies open every week