Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/SD/Sioux Falls
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Sioux Falls, SD

Studies commonly pay $75 to $4,500 per completed study

266 clinical trials are currently recruiting participants within 30 miles of Sioux Falls. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

266studies recruiting
4+research centers nearby
2condition categories
Live from the NIH registry

Studies recruiting near Sioux Falls right now

Top 25 of 266 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

HPV-unrelated Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 81 participants sought
Sanford Medical Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Washington University School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT04966481)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
Sanford Cancer Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Migraine Phase 3 Interventional 200 participants sought
Avera Medical Group Pediatric Specialists — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT06616194)

Real-World Data Collection of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis When Used in Covered Endovascular Reconstruction of the Aortic Bifurcation (CERAB) to Treat Aortoiliac Occlusive Disease

Aortoiliac Occlusive Disease N/A Observational 158 participants sought
Sanford Clinical Vascular Associates — Sioux Falls, South Dakota (0.3 mi) · Sponsor: W.L.Gore & Associates
See eligibility & contact on ClinicalTrials.gov (NCT06872905)

A Study to Assess Real-World Use and Outcomes of TAR-200 for Participants With Non-Muscle Invasive Bladder Cancer (NMIBC) in the United States

Non-Muscle Invasive Bladder Neoplasms N/A Observational 150 participants sought
Urology Specialists of South Dakota — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07309445)

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

Cataract Phase 3 Interventional 528 participants sought
Vance Thompson Vision — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Melt Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06383273)

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Multiple conditions Phase 2 Interventional 150 participants sought
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05136196)

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Ganglioneuroblastoma, Nodular, Neuroblastoma Phase 3 Interventional 478 participants sought
Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06172296)

A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer

Endometrial Cancer Phase 3 Interventional 480 participants sought
Sanford Cancer Center — Sioux Falls, South Dakota (0.3 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT06340568)

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

Ovarian Cancer, Fallopian Tube Cancer Phase 2 Interventional 220 participants sought
Avera Cancer Institute Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Regeneron Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06787612)

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma Phase 3 Interventional 1,450 participants sought
Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04566328)

A Real-world Chronic Myelogenous Leukemia (CML) Patient Disease Registry to Describe Patient Experience and Clinical Outcomes Among Patients With CML Receiving Approved First or Second Line Tyrosine Kinase Inhibitor (TKI) Therapy

Chronic Myelogenous Leukemia - Chronic Phase N/A Observational 1,000 participants sought
Avera Cancer — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07091019)

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms Phase 3 Interventional 1,314 participants sought
Avera Cancer Institute- Research ( Site 0094) — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06136650)

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 2,000 participants sought
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05564390)

A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant Phase 3 Interventional 800 participants sought
Avera Medical Group — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT07225946)

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer Phase 3 Interventional 4,300 participants sought
Research Site — Sioux Falls, South Dakota (0.3 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05774951)

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma, Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7 Phase 2, Phase 3 Interventional 613 participants sought
Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota (0.3 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01810913)

A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

Triple Negative Breast Cancer, Breast Cancer Phase 1, Phase 2 Interventional 360 participants sought
Avera Cancer Institute — Sioux Falls, South Dakota (0.3 mi) · Sponsor: Day One Biopharmaceuticals, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05377996)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota (0.3 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)
Google-rated

Top-rated research centers in Sioux Falls

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Avera Research Institute — Sioux Falls

6001 S Sharon Ave, Sioux Falls, SD 57108
(605) 504-3154

Sanford Research

★ 5.0
2301 East 60th St N, Sioux Falls, SD 57104
(605) 312-6300

Sanford Imagenetics

★ 4.1
1321 W 22nd St, Sioux Falls, SD 57105
(605) 404-4000

Circle Clinical Research

(605) 215-1159

Clinical trials in Sioux Falls: what's recruiting

The Sioux Falls area currently has 266 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Sioux Falls, the most active research areas are:

  • Cancer & Oncology17 studies
  • Diabetes & Metabolism1 studies

Every listing shows the study phase, the recruiting site and its distance from Sioux Falls, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Sioux Falls

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Sioux Falls participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Sioux Falls?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Sioux Falls safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Sioux Falls, SD?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Sioux Falls?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Sioux Falls.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Sioux Falls typically complete one or two studies per year.

Paid clinical trials near Sioux Falls

Other metros within reach

Omaha, NE597 Lincoln, NE161 Fargo, ND206 Des Moines, IA226 Minneapolis, MN1,085 St. Paul, MN1,085 Topeka, KS110 Kansas City, KS1,011

New paid studies open every week

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