Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MN/St. Paul
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in St. Paul, MN

Studies commonly pay $75 to $4,500 per completed study

1,085 clinical trials are currently recruiting participants within 30 miles of St. Paul. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,085studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near St. Paul right now

Top 25 of 1,085 recruiting studies, sorted by proximity — each links to its official registry page

Open Label, Controlled, Post Marketing, Registry Study of Ribociclib (Ribo) Treatment Adherence and Patient Reported Outcomes in Participants Using ReX Technology Platform

Any Solid Oral Medication N/A Interventional 200 participants sought
Allina — Minneapolis, Minnesota (8.1 mi) · Sponsor: Dosentrx Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06344416)

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Minnesota Oncology Hematology, P.A. — Minneapolis, Minnesota (8.1 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
VitreoRetinal Surgery, PLLC. — Minneapolis, Minnesota (8.1 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders

Bipolar Disorder N/A Observational 200 participants sought
Minneapolis VA Health Care System, Minneapolis, MN — Minneapolis, Minnesota (8.1 mi) · Sponsor: VA Office of Research and Development
See eligibility & contact on ClinicalTrials.gov (NCT06204705)

A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033)

Renal Cell Carcinoma Phase 3 Interventional 904 participants sought
Metro-Minnesota Community Clinical Oncology ( Site 0144) — Saint Louis Park, Minnesota (11.9 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT07227402)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
Regions Hospital — Saint Paul, Minnesota (0.6 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

BAFFR-targeting CAR T Cells for Patients With Relapsed or Refractory B-NHL

Relapsed or Refractory B-cell Non-Hodgkin's Lymphoma Phase 1 Interventional 36 participants sought
University of Minnesota — Minneapolis, Minnesota (8.1 mi) · Sponsor: PeproMene Bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT05370430)

Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial

Tibial Fractures, Pain Phase 3 Interventional 1,000 participants sought
Hennepin Health — Minneapolis, Minnesota (8.1 mi) · Sponsor: Major Extremity Trauma Research Consortium
See eligibility & contact on ClinicalTrials.gov (NCT07006675)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Retina Consultants of Minnesota PLLC — Saint Louis Park, Minnesota (11.9 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Ulcerative Colitis, Crohn's Disease Phase 3 Interventional 240 participants sought
MNGI Digestive Health PA-Plymouth — Minneapolis, Minnesota (8.1 mi) · Sponsor: Takeda
See eligibility & contact on ClinicalTrials.gov (NCT05442567)

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck Phase 1 Interventional 1,006 participants sought
Allina Health Cancer Institute - United Hospital — Saint Paul, Minnesota (0.6 mi) · Sponsor: Seagen, a wholly owned subsidiary of Pfizer
See eligibility & contact on ClinicalTrials.gov (NCT04389632)

Myeloablative Consolidation Therapy and Tandem Autologous Stem Cell Rescue in Patients With High-Risk Neuroblastoma

Neuroblastoma Phase 2 Interventional 12 participants sought
Masonic Cancer Center, University of Minnesota — Minneapolis, Minnesota (8.1 mi) · Sponsor: Masonic Cancer Center, University of Minnesota
See eligibility & contact on ClinicalTrials.gov (NCT02605421)

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Brain Cancer, Breast Cancer N/A Observational 7,000 participants sought
Allina Health Cancer Institute — Minneapolis, Minnesota (8.1 mi) · Sponsor: Adela, Inc
See eligibility & contact on ClinicalTrials.gov (NCT05366881)

Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)

Eating Disorders N/A Interventional 144 participants sought
University of Minnesota — Minneapolis, Minnesota (8.1 mi) · Sponsor: University of Minnesota
See eligibility & contact on ClinicalTrials.gov (NCT06631729)

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

Systemic Lupus Erythematosus Phase 3 Interventional 100 participants sought
Research Site — Saint Paul, Minnesota (0.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05835310)

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

Multiple conditions Phase 2 Interventional 150 participants sought
Regions Hospital — Saint Paul, Minnesota (0.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05136196)

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

Atopic Dermatitis Phase 3 Interventional 180 participants sought
Minnesota Clinical Study Center — New Brighton, Minnesota (9.4 mi) · Sponsor: Organon and Co
See eligibility & contact on ClinicalTrials.gov (NCT07265479)
Google-rated

Top-rated research centers in St. Paul

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Clinical Research Institute

★ 4.9
825 Nicollet Mall #1135, Minneapolis, MN 55402
(612) 333-2200
"The best part of this location is that there is a dedicated bike trail past all the traffic from the western suburbs."
— Jesse Kortes, 4★

Nucleus Network Minneapolis Clinic

★ 4.3
1000 Westgate Dr #149, St Paul, MN 55114
(651) 641-2900
"Absolutely outstanding in every way. A+. Ten stars! The staff was the BEST in America! So amazing I just can’t say enough about ALL of them. So dedic…"
— Jennifer, 5★

Prism Clinical Research

1000 Westgate Dr #149, St Paul, MN 55114

Minnesota Clinical Study Center

★ 4.3
119 14th St NW, New Brighton, MN 55112
(763) 571-4200
"I responded to an advertisement in the Strib about a medical study they were conducting. People on the phone were very polite and briefly explained …"
— sven svenson, 1★

University of Minnesota Clinical Research Unit (CRU)

516 Delaware St SE, Minneapolis, MN 55455

Comprehensive Research Group

★ 4.7
2520 Broadway St NE, Minneapolis, MN 55413
(612) 781-3400
"Super, super nice people that work there. They are very organized in how they do things."
— Lisa Bjorken, 5★

UMN Oral Health Clinical Research Center (OHCRC)

Malcolm Moos Health Sciences Tower, 515 Delaware St SE, Minneapolis, MN 55455

Wilder Foundation

★ 4.4
451 Lexington Pkwy N, St Paul, MN 55104
(651) 280-2000
"I volunteered with the meals on wheels program through Wilder Foundation. I asked for a letter of recommendation and even after many follow up emails…"
— Beth T, 1★

Epidemiology Clinical Research Center

★ 5.0
1100 Washington Ave S, Minneapolis, MN 55415
(612) 626-9199

Clinical trials in St. Paul: what's recruiting

The St. Paul area currently has 1,085 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to St. Paul, the most active research areas are:

  • Cancer & Oncology9 studies
  • Immune & Skin3 studies
  • Liver & Kidney2 studies
  • Heart & Vascular1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from St. Paul, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in St. Paul

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

St. Paul participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in St. Paul pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
Do I need to be sick to join a clinical trial in St. Paul?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in St. Paul safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How often do new paid studies open in St. Paul?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of St. Paul.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in St. Paul typically complete one or two studies per year.

Paid clinical trials near St. Paul

Other metros within reach

Minneapolis, MN1,085 Cedar Rapids, IA590 Des Moines, IA226 Sioux Falls, SD266 Madison, WI520 Fargo, ND206 Davenport, IA42 Omaha, NE597

More of MN

Minneapolis1,085

New paid studies open every week

Get an email when a new clinical trial starts recruiting within 30 miles of your ZIP code. No spam — only real studies from the NIH registry.

By subscribing you agree to receive study alert emails. Unsubscribe anytime in one click.

Get free trial alerts