Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MO/St. Louis
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in St. Louis, MO

Studies commonly pay $75 to $4,500 per completed study

1,481 clinical trials are currently recruiting participants within 30 miles of St. Louis. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

1,481studies recruiting
9+research centers nearby
5condition categories
Live from the NIH registry

Studies recruiting near St. Louis right now

Top 25 of 1,481 recruiting studies, sorted by proximity — each links to its official registry page

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

PIK3CA Mutation, HER2- Negative Breast Cancer Phase 3 Interventional 540 participants sought
Washington University School of Medicine- Siteman Cancer Center — St Louis, Missouri (2.6 mi) · Sponsor: Relay Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06982521)

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Midwest Vision Research Foundation — Chesterfield, Missouri (18.0 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer

Advanced Breast Cancer Phase 2 Interventional 24 participants sought
Research Site — St Louis, Missouri (2.6 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07427394)

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

Solid Tumor, Non-Small-Cell Lung Cancer Phase 1 Interventional 364 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Astellas Pharma Inc
See eligibility & contact on ClinicalTrials.gov (NCT07094204)

Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery

Spinal Fusion, Hyperglycemia N/A Interventional 50 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Alexander T. Yahanda
See eligibility & contact on ClinicalTrials.gov (NCT07218133)

ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

Diffuse Intrinsic Pontine Gliomas (DIPG), Progressive DIPG Phase 2 Interventional 60 participants sought
St. Louis Children's Hospital — St Louis, Missouri (2.6 mi) · Sponsor: Nationwide Children's Hospital
See eligibility & contact on ClinicalTrials.gov (NCT06838676)

Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design

Fibromyalgia Phase 3 Interventional 620 participants sought
Clinical Research Site — Town and Country, Missouri (11.9 mi) · Sponsor: Axsome Therapeutics, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07398417)

Harnessing Neuroplasticity to Enhance Functional Recovery During Chronic Recovery From Upper Extremity Nerve Repair

Hand Transplantation, Peripheral Nerve Injuries N/A Interventional 180 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: University of Missouri-Columbia
See eligibility & contact on ClinicalTrials.gov (NCT03610763)

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

HPV-unrelated Head and Neck Squamous Cell Carcinoma Phase 3 Interventional 81 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Washington University School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT04966481)

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

Lymphoma, B-Cell, Lymphoma, Non-Hodgkin (NHL) Phase 1 Interventional 106 participants sought
Washington University School of Medicine/Siteman Cancer Center — St Louis, Missouri (2.6 mi) · Sponsor: Umoja Biopharma
See eligibility & contact on ClinicalTrials.gov (NCT06528301)

Zanzalintinib in Combination With Ipilimumab and Nivolumab in Patients With Metastatic Soft Tissue Sarcoma

Metastatic Soft-tissue Sarcoma Phase 1 Interventional 18 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Washington University School of Medicine
See eligibility & contact on ClinicalTrials.gov (NCT06968988)

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction, Concentric Hypertrophy N/A Interventional 105 participants sought
Prairie Education and Research Cooperative-St. Elizabeth's — O'Fallon, Illinois (18.3 mi) · Sponsor: Medtronic Cardiac Rhythm and Heart Failure
See eligibility & contact on ClinicalTrials.gov (NCT05839730)

A Study of Zunveyl on Safety, Tolerability, Neuropsychiatric Symptoms, and Caregiver Distress in Alzheimer's Disease (RESOLVE)

Alzheimer Disease Phase 4 Interventional 150 participants sought
Tekton Research Saint Louis Psychiatry — St Louis, Missouri (2.6 mi) · Sponsor: Alpha Cognition, Inc
See eligibility & contact on ClinicalTrials.gov (NCT07633470)

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

Metastatic Castration-Resistant Prostate Carcinoma, Metastatic Prostate Adenocarcinoma Phase 3 Interventional 1,524 participants sought
Missouri Baptist Medical Center — St Louis, Missouri (2.6 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07200830)

Phase 2 Study of Inhaled SNG001 in Mechanically Ventilated Patients With Respiratory Viral Infection

Viral Pneumonia Phase 2 Interventional 550 participants sought
Washington University in St. Louis — St Louis, Missouri (2.6 mi) · Sponsor: Synairgen Research Ltd.
See eligibility & contact on ClinicalTrials.gov (NCT06999603)

The Vanguard Study: Testing a New Way to Screen for Cancer

Bladder Carcinoma, Breast Carcinoma N/A Interventional 24,000 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06995898)

Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors

Solid Tumor Phase 2 Interventional 55 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: Emory University
See eligibility & contact on ClinicalTrials.gov (NCT04469530)

Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes

Gastrointestinal Symptoms, Constipation N/A Interventional 30 participants sought
Lindenwood University — Saint Charles, Missouri (16.3 mi) · Sponsor: Lindenwood University
See eligibility & contact on ClinicalTrials.gov (NCT07388264)

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 188 participants sought
Washington University School of Medicine — St Louis, Missouri (2.6 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04671667)

Promoting Improved Functioning Among People Experiencing Stressful Situations

Acute Stress Reaction N/A Interventional 450 participants sought
Washington University, St. Louis — St Louis, Missouri (2.6 mi) · Sponsor: University of North Carolina, Chapel Hill
See eligibility & contact on ClinicalTrials.gov (NCT06482567)
Google-rated

Top-rated research centers in St. Louis

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Clinical Research Training Center CRTC

★ 5.0
4950 Children's Pl, St. Louis, MO 63110
(314) 454-8960

Clinical Research Center

★ 4.3
969 N Mason Rd Ste 240, Creve Coeur, MO 63141
(314) 514-8509
"Great staff ... Doctor T ... BEST ... concerned for their patients. I have been in the various asthma studies over the years. Would recommend C…"
— W Joseph Gallagher, 5★

CRConcierge

1409 Washington Ave Ste 504, St. Louis, MO 63103

American Medical Research Center

★ 3.0
3737 Kingshighway Blvd, St. Louis, MO 63115
(314) 917-1682
"Contributing to research so that we can have new medicine for our disease!"
— Mohammed Nezam, 5★

Center for the Study of Itch

★ 3.0
St. Louis, MO 63110
(314) 362-8171

Saint Louis University Center for Vaccine Development

★ 4.3
1100 S Grand Blvd, St. Louis, MO 63104
(314) 977-6333
"I always find the staff very accommodating from front desk through to nurses/doctor. Have participated 3x in trials/studies. Have been glad to volu…"
— B Dodson, 5★

Center for Clinical Pharmacology

2 Pharmacy Place, St. Louis, MO 63110
(314) 367-8700

WashU Jeffrey T. Fort Neuroscience Research Building (Fort Labs)

★ 4.9
4370 Duncan Ave, St. Louis, MO 63110
(314) 362-3033
"Some of the best minds coming together in a state-of-the-art building."
— Jan Kubanek, 5★

Sundance Clinical Research

★ 4.8
711 Old Ballas Rd #105, St. Louis, MO 63141
(314) 567-3377
"This place is absolutely amazing. Staff is so knowledgeable. Customer care is on point, so professional. I think this is the best medical research ex…"
— Tiff Stockton, 5★

Clinical trials in St. Louis: what's recruiting

The St. Louis area currently has 1,481 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to St. Louis, the most active research areas are:

  • Cancer & Oncology11 studies
  • Heart & Vascular3 studies
  • Liver & Kidney2 studies
  • Immune & Skin1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from St. Louis, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in St. Louis

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

St. Louis participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in St. Louis pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in St. Louis, MO?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in St. Louis?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in St. Louis typically complete one or two studies per year.

Paid clinical trials near St. Louis

Other metros within reach

Springfield, IL192 Columbia, MO264 Peoria, IL219 Champaign, IL167 Evansville, IN67 Davenport, IA42 Springfield, MO157 Memphis, TN578

More of MO

Kansas City1,000 Columbia264 Springfield157

New paid studies open every week

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