Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/MD/Frederick
Updated July 2026 from ClinicalTrials.gov

Paid Clinical Trials in Frederick, MD

Studies commonly pay $75 to $4,500 per completed study

261 clinical trials are currently recruiting participants within 30 miles of Frederick. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

261studies recruiting
9+research centers nearby
6condition categories
Live from the NIH registry

Studies recruiting near Frederick right now

Top 25 of 261 recruiting studies, sorted by proximity — each links to its official registry page

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration Phase 4 Interventional 188 participants sought
Cumberland Valley Retina Consultants PC — Hagerstown, Maryland (21.7 mi) · Sponsor: Genentech, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT04853251)

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

Geographic Atrophy, Macular Degeneration N/A Observational 500 participants sought
Cumberland Valley Retina Consultants,P.C. — Hagerstown, Maryland (21.7 mi) · Sponsor: Astellas Pharma Global Development, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06779773)

A Study to Evaluate Efficacy and Safety of MELT-300 for Procedural Sedation in Subjects Undergoing Cataract Extraction With Lens Replacement (CELR)

Cataract Phase 3 Interventional 528 participants sought
Maryland Vision Institute — Hagerstown, Maryland (21.7 mi) · Sponsor: Melt Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06383273)

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

HIV Infections, Substance Use Disorders N/A Interventional 360 participants sought
Frederick County Health Department, Street Safe Program — Frederick, Maryland (1.4 mi) · Sponsor: Johns Hopkins University
See eligibility & contact on ClinicalTrials.gov (NCT06103370)

DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study

Pleuropulmonary Blastoma, Cystic Nephroma N/A Observational 1,500 participants sought
National Cancer Institute - Shady Grove — Rockville, Maryland (27.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT01247597)

A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

Atopic Dermatitis Phase 3 Interventional 180 participants sought
Lawrence J Green, MD LLC — Rockville, Maryland (27.9 mi) · Sponsor: Organon and Co
See eligibility & contact on ClinicalTrials.gov (NCT07265479)

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

NonSegmental Vitiligo Phase 3 Interventional 180 participants sought
Dermatology Associates Pc — Rockville, Maryland (27.9 mi) · Sponsor: Incyte Corporation
See eligibility & contact on ClinicalTrials.gov (NCT06548360)

Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma Phase 3 Interventional 1,450 participants sought
Frederick Memorial Hospital — Frederick, Maryland (1.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT04566328)

Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors

Healthy Phase 3 Interventional 60,000 participants sought
C.W. Bill Young Marrow Donor Center — Rockville, Maryland (27.9 mi) · Sponsor: Center for International Blood and Marrow Transplant Research
See eligibility & contact on ClinicalTrials.gov (NCT00785525)

Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer

Advanced Endometrial Carcinoma, Recurrent Endometrial Carcinoma Phase 3 Interventional 255 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT07198074)

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Bipolar Disorder Type I With Mania Phase 3 Interventional 450 participants sought
CBH Health — Gaithersburg, Maryland (23.1 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT06929273)

A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer Phase 3 Interventional 4,300 participants sought
Research Site — Frederick, Maryland (1.4 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT05774951)

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Ovarian Carcinoma N/A Interventional 1,956 participants sought
WVUH-Berkely Medical Center — Martinsburg, West Virginia (29.4 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT04251052)

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

Neovascular Age-Related Macular Degeneration (nAMD), Wet AMD Phase 3 Interventional 284 participants sought
Adverum Clinical Site 197 — Hagerstown, Maryland (21.7 mi) · Sponsor: Adverum Biotechnologies, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT07482176)

A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01

Diabetic Retinopathy, NPDR - Non Proliferative Diabetic Retinopathy Phase 2 Interventional 100 participants sought
Cumberland Valley Retina Consultants — Hagerstown, Maryland (21.7 mi) · Sponsor: Vantage Biosciences Ltd
See eligibility & contact on ClinicalTrials.gov (NCT06770933)

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Breast Carcinoma, Colorectal Carcinoma N/A Observational 2,000 participants sought
William E Kahlert Regional Cancer Center/Sinai Hospital — Westminster, Maryland (24.4 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT06418204)

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

Non-small Cell Lung Cancer Phase 2, Phase 3 Interventional 1,260 participants sought
Frederick Health Hospital- James M Stockman Cancer Institute — Frederick, Maryland (1.4 mi) · Sponsor: BioNTech SE
See eligibility & contact on ClinicalTrials.gov (NCT06712316)

Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos

Complex Aneuploidy, Chaotic Aneuploidy N/A Observational 280 participants sought
Shady Grove Fertility — Rockville, Maryland (27.9 mi) · Sponsor: Shady Grove Fertility Reproductive Science Center
See eligibility & contact on ClinicalTrials.gov (NCT07227116)

A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMD

Geographic Atrophy of the Macula Phase 2 Interventional 110 participants sought
Cumberland Valley Retina Consultants — Hagerstown, Maryland (21.7 mi) · Sponsor: Galimedix Therapeutics Inc
See eligibility & contact on ClinicalTrials.gov (NCT06659549)

Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder Phase 3 Interventional 850 participants sought
Neurocrine Clinical Site — Gaithersburg, Maryland (23.1 mi) · Sponsor: Neurocrine Biosciences
See eligibility & contact on ClinicalTrials.gov (NCT06966401)
Google-rated

Top-rated research centers in Frederick

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Frederick National Laboratory for Cancer Research

★ 4.5
8560 Progress Drive, Frederick, MD 21701
(301) 846-1000

Work NCI Advanced Technology Research Facility

★ 4.9
8560 Progress Drive, Frederick, MD 21701

Concerted Care Group Frederick

★ 4.8 (83 reviews)
92 Thomas Johnson Dr Ste 100, Frederick, MD 21702
(240) 815-7300
"Kelly B the front receptionist is by far the BEST... First off she makes you feel at home when you walk through the door until the moment you walk ou…"
— Melissa Allen, 5★

National Cancer Institute -- Frederick Campus

★ 4.4
1050 Boyles St, Frederick, MD 21702
(800) 422-6237

HIV Dynamics and Replication Program

★ 4.0
1050 Boyles St Bldg 535, Rm 309, Frederick, MD 21702

Community Radiology Associates | Frederick Imaging Center

★ 4.8
67 Thomas Johnson Dr #4, Frederick, MD 21702
(888) 601-0943
"It was great people were very nice<br>And understanding"
— Travis Shane, 5★

IC Health Services, Inc.

★ 4.4 (7 reviews)
15 N Court St #204, Frederick, MD 21701
(240) 698-3678
"I must say, Dr. Chidinma of IC Health Services is amazing. She is caring, open-minded, compassionate, and knowledgeable. She provides the best treatm…"
— Marcus Kometa, 5★

The Center for Holistic Wellness

★ 5.0
6 W 2nd St 1st Floor, Frederick, MD 21701
(240) 739-5081
"The Center for Holistic Wellness providers are very compassionate and caring. I believe Dr. Jedidiah Smith and Mona Theil are truly healers for my mi…"
— Robin Lewis, 5★

Mesa Science Associates Inc.

321 Ballenger Center Dr Ste 125, Frederick, MD 21703
(301) 514-6248

Clinical trials in Frederick: what's recruiting

The Frederick area currently has 261 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Frederick, the most active research areas are:

  • Cancer & Oncology7 studies
  • Brain & Mental Health5 studies
  • Heart & Vascular2 studies
  • Diabetes & Metabolism2 studies
  • Lungs & Breathing1 studies

Every listing shows the study phase, the recruiting site and its distance from Frederick, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Frederick

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Frederick participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

Do I need to be sick to join a clinical trial in Frederick?
No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.
Are clinical trials in Frederick safe?
Every trial on this page is registered on ClinicalTrials.gov, the official NIH registry, and is overseen by an Institutional Review Board (IRB). Before joining you receive an informed consent document detailing procedures, risks and compensation. Participation is voluntary and you can withdraw at any time.
How do I join a study in Frederick, MD?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
How often do new paid studies open in Frederick?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Frederick.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Frederick typically complete one or two studies per year.

Paid clinical trials near Frederick

Other metros within reach

Hagerstown, MD112 Arlington, VA2,345 Washington, DC2,376 Alexandria, VA2,303 Baltimore, MD1,648 York, PA459 Harrisburg, PA412 Fredericksburg, VA34

More of MD

Baltimore1,648 Hagerstown112

New paid studies open every week

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