Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/FL/Port St. Lucie
Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Port St. Lucie, FL

Studies commonly pay $75 to $4,500 per completed study

104 clinical trials are currently recruiting participants within 30 miles of Port St. Lucie. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

104studies recruiting
9+research centers nearby
7condition categories
Live from the NIH registry

Studies recruiting near Port St. Lucie right now

Top 25 of 104 recruiting studies, sorted by proximity — each links to its official registry page

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NSCLC (Non-small Cell Lung Cancer), Non-Small Cell Lung Cancer Phase 3 Interventional 590 participants sought
Cleveland Clinic Martin North — Stuart, Florida (10.1 mi) · Sponsor: Revolution Medicines, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06881784)

Symptoms and Functions in Patients With COPD and Chronic Bronchitis Switching From CIG to THS

COPD, Smoking N/A Interventional 290 participants sought
CDC Research Institute — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Philip Morris Products S.A.
See eligibility & contact on ClinicalTrials.gov (NCT07108166)

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8 Phase 3 Interventional 1,209 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05946213)

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

Metabolic Dysfunction-Associated Steatotic Liver Disease Phase 3 Interventional 4,500 participants sought
Health Awareness — Jupiter, Florida (29.9 mi) · Sponsor: Eli Lilly and Company
See eligibility & contact on ClinicalTrials.gov (NCT07165028)

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (PPV-MF) Phase 3 Interventional 460 participants sought
The Anderson Family Cancer Institute — Jupiter, Florida (29.9 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07357727)

Study of Lenacapavir, Teropavimab, and Zinlirvimab Versus Cabotegravir and Rilpivirine in Virologically Suppressed Adults With HIV-1 on Oral Daily Antiretroviral Therapy

HIV Infections Phase 3 Interventional 590 participants sought
Midway Immunology and Research Center — Ft. Pierce, Florida (12.2 mi) · Sponsor: Gilead Sciences
See eligibility & contact on ClinicalTrials.gov (NCT07682961)

A Study of a Thyroid Hormone Receptor Beta Isoform (THRβ) Agonist and an Semicarbazide Sensitive Amine Oxidase (SSAO) Inhibitor, Alone and in Combination, in Adults With Presumed Metabolic Dysfunction-associated Steatohepatitis (MASH)

Metabolic Dysfunction-associated Steatohepatitis Phase 2 Interventional 160 participants sought
Health Awareness, Inc. — Jupiter, Florida (29.9 mi) · Sponsor: Eccogene
See eligibility & contact on ClinicalTrials.gov (NCT07288138)

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

Leukemia, Myeloid, Acute Phase 3 Interventional 600 participants sought
Jupiter Research — Jupiter, Florida (29.9 mi) · Sponsor: Janssen Research & Development, LLC
See eligibility & contact on ClinicalTrials.gov (NCT06852222)

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

Endometrial Cancer, Malignant Solid Tumour Phase 3 Interventional 800 participants sought
Research Site — Jupiter, Florida (29.9 mi) · Sponsor: AstraZeneca
See eligibility & contact on ClinicalTrials.gov (NCT07044336)

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Relapsing Multiple Sclerosis Phase 3 Interventional 400 participants sought
Vero Beach Neurology — Vero Beach, Florida (24.8 mi) · Sponsor: Novartis Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT06846281)

A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease

Alzheimers Disease Phase 3 Interventional 800 participants sought
Alzheimer's Research and Treatment Center — Stuart, Florida (10.1 mi) · Sponsor: Hoffmann-La Roche
See eligibility & contact on ClinicalTrials.gov (NCT07170150)

Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease

High Risk Cardiovascular Disease, Hypertension Phase 3 Interventional 11,000 participants sought
Clinical Trial Site — Jensen Beach, Florida (9.9 mi) · Sponsor: Alnylam Pharmaceuticals
See eligibility & contact on ClinicalTrials.gov (NCT07181109)

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer (CRC) Phase 3 Interventional 600 participants sought
Clinical Study Site — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Summit Therapeutics
See eligibility & contact on ClinicalTrials.gov (NCT07228832)

Efficacy and Safety of IMVT-1402 in Adult Participants With Primary Sjogren's Disease With Moderate to Severe Systemic Disease Activity

Primary Sjögren's Syndrome Phase 2 Interventional 180 participants sought
Site Number - 1021 — Jupiter, Florida (29.9 mi) · Sponsor: Immunovant Sciences GmbH
See eligibility & contact on ClinicalTrials.gov (NCT06979531)

Study of an Injectable Regimen of GS-3242 With Lenacapavir Compared to Biktarvy in People New to HIV-1 Treatment

HIV-1-infection Phase 2, Phase 3 Interventional 700 participants sought
Midway Immunology and Research Center — Ft. Pierce, Florida (12.2 mi) · Sponsor: Gilead Sciences
See eligibility & contact on ClinicalTrials.gov (NCT07708727)

RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain

Pain N/A Observational 4,800 participants sought
Louis J. Raso, MD, PA — Jupiter, Florida (29.9 mi) · Sponsor: Boston Scientific Corporation
See eligibility & contact on ClinicalTrials.gov (NCT01719055)

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis Phase 3 Interventional 1,350 participants sought
89bio Clinical Study Site — Jupiter, Florida (29.9 mi) · Sponsor: 89bio, Inc.
See eligibility & contact on ClinicalTrials.gov (NCT06318169)

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

Endometrial Carcinoma, Endometrial Clear Cell Adenocarcinoma Phase 3 Interventional 360 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05256225)

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Triple-Negative Breast Cancer Phase 3 Interventional 1,530 participants sought
Cleveland Clinic Martin North Hospital ( Site 0114) — Stuart, Florida (10.1 mi) · Sponsor: Merck Sharp & Dohme LLC
See eligibility & contact on ClinicalTrials.gov (NCT06393374)

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia Phase 3 Interventional 466 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT07321652)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought
Jupiter Medical Center — Jupiter, Florida (29.9 mi) · Sponsor: ECOG-ACRIN Cancer Research Group
See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Evaluation of Efficacy and Safety of Suzetrigine (SUZ) for Pain Associated With Diabetic Peripheral Neuropathy

Diabetic Peripheral Neuropathic Pain Phase 3 Interventional 734 participants sought
Health Awareness, Inc. - Port St. Lucie — Port Saint Lucie, Florida (2.5 mi) · Sponsor: Vertex Pharmaceuticals Incorporated
See eligibility & contact on ClinicalTrials.gov (NCT07231419)

Real-world Experience Using Nemolizumab in the Treatment of Moderate-to-Severe Atopic Dermatitis in Adolescents & Adults

Atopic Dermatitis N/A Observational 1,000 participants sought
Galderma Investigational Site 7101 — Jupiter, Florida (29.9 mi) · Sponsor: Galderma R&D
See eligibility & contact on ClinicalTrials.gov (NCT06988605)

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

HR+/HER2- Breast Cancer Phase 3 Interventional 1,056 participants sought
Hematology Oncology Associates of the Treasure Coast — Port Saint Lucie, Florida (2.5 mi) · Sponsor: BeOne Medicines
See eligibility & contact on ClinicalTrials.gov (NCT07492641)
Actively enrolling

Studies you may be able to join near Port St. Lucie

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Port St. Lucie

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

Florida Research and Innovation Center

★ 5.0
9801 SW Discovery Wy, Port St. Lucie, FL 34987

Health Awareness

★ 4.6
1801 SE Hillmoor Dr, Port St. Lucie, FL 34952
(772) 777-3344
"They are always nice and professional and respect your time."
— Julia Terry, 5★

Midway Immunology Research Center

360 E Midway Rd, Fort Pierce, FL 34982
(772) 595-9830

Soma Medical Center, P.A. Adults - Port Saint Lucie

★ 4.6
1170 SW Bayshore Blvd, Port St. Lucie, FL 34983
(772) 309-0020
"I love this medical center. Every visit gets better and better. Everyone is very knowledgeable and professional. They make you feel very comfortable.…"
— PenningtonSherrod, 5★

Brain Matters Research

★ 5.0
900 SE Salerno Rd, Stuart, FL 34997
(772) 223-7880
"They are great ! 👍 please join to cure alzheimers"
— Roberta Pietz, 5★

Alzheimer's Treatment Centers of America

★ 4.0
266 NW Peacock Blvd Ste 204, Port St. Lucie, FL 34986
(772) 298-4477
"Unprofessional and Disappointing Experience - Avoid at All Costs<br>My recent visit to this clinic was, frankly, a waste of time and incredibly frust…"
— Michael Lavenstein, 1★

Comprehensive Clinical Research

★ 4.9
603 Village Blvd #301, West Palm Beach, FL 33409
(561) 478-3177
"Great place employees are very nice"
— Diane Atkins, 5★

Health Synergy Clinical Research

★ 5.0
308 NW 5th Ave, Okeechobee, FL 34972
(863) 824-7989

Florida Cancer Specialists & Research Institute

★ 4.7 (241 reviews)
301 SE Ocean Blvd Suite 102, Stuart, FL 34994
(772) 287-4061
"dr Leary is wonderful, caring , and informative , she put me at rest as soon as i met her and all i can say is thank you from the bottom of my heart …"
— Harry Elsbury, 5★

Clinical trials in Port St. Lucie: what's recruiting

The Port St. Lucie area currently has 104 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Port St. Lucie, the most active research areas are:

  • Cancer & Oncology11 studies
  • Diabetes & Metabolism4 studies
  • Liver & Kidney3 studies
  • Lungs & Breathing1 studies
  • Brain & Mental Health1 studies

Every listing shows the study phase, the recruiting site and its distance from Port St. Lucie, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Port St. Lucie

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Port St. Lucie participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Port St. Lucie pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Port St. Lucie, FL?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
What is the difference between a research center and a hospital study in Port St. Lucie?
Dedicated research centers (listed on this page with their Google ratings) run studies as their core business — often healthy-volunteer and vaccine studies with structured compensation. Hospital and university studies tend to focus on patients with specific conditions. Both types are registered and IRB-supervised.
How often do new paid studies open in Port St. Lucie?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Port St. Lucie.

Paid clinical trials near Port St. Lucie

Other metros within reach

Palm Bay, FL72 Fort Lauderdale, FL1,991 Pembroke Pines, FL1,984 Hollywood, FL1,984 Hialeah, FL1,940 Kissimmee, FL925 Winter Haven, FL162 Miami, FL1,915

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Port St. Lucie Bladder Issues Due To Spinal Cord Injury in Port St. Lucie All conditions

More of FL

Fort Lauderdale1,991 Pembroke Pines1,984 Hollywood1,984 Hialeah1,940 Miami1,915 St. Petersburg1,359 Tampa1,339 Deltona953 Orlando941 Kissimmee925 Jacksonville921 Gainesville532

New paid studies open every week

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