Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only

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Updated September 2026 from ClinicalTrials.gov

Paid Clinical Trials in Santa Maria, CA

Studies commonly pay $75 to $4,500 per completed study

89 clinical trials are currently recruiting participants within 30 miles of Santa Maria. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

89studies recruiting

4+research centers nearby

4condition categories

Live from the NIH registry

Studies recruiting near Santa Maria right now

Top 25 of 89 recruiting studies, sorted by proximity — each links to its official registry page

A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

Metabolic Dysfunction-Associated Steatohepatitis, Non-alcoholic Fatty Liver Disease Phase 2 Interventional 42 participants sought

GSK Investigational Site — Santa Maria, California (1.4 mi) · Sponsor: GlaxoSmithKline

See eligibility & contact on ClinicalTrials.gov (NCT06920043)

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm N/A Observational 5,000 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: National Cancer Institute LAO

See eligibility & contact on ClinicalTrials.gov (NCT02474160)

A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

Non-alcoholic Fatty Liver Disease Phase 3 Interventional 1,250 participants sought

GSK Investigational Site — Santa Maria, California (1.4 mi) · Sponsor: GlaxoSmithKline

See eligibility & contact on ClinicalTrials.gov (NCT07221188)

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 Phase 2 Interventional 240 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05327686)

Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer

Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 Phase 3 Interventional 1,100 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06632327)

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Myasthenia Gravis, Generalized Phase 2 Interventional 30 participants sought

Tri Valley Neurology Medical Associates Inc. — Mission Hills, California (17.1 mi) · Sponsor: Vertex Pharmaceuticals Incorporated

See eligibility & contact on ClinicalTrials.gov (NCT07501702)

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma Phase 3 Interventional 247 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04269902)

Treatment of Radiation and Cisplatin Induced Toxicities with Tempol

Mucositis, Nephrotoxicity Phase 2 Interventional 120 participants sought

Central Coast Medical Oncology — Santa Maria, California (1.4 mi) · Sponsor: Matrix Biomed, Inc.

See eligibility & contact on ClinicalTrials.gov (NCT03480971)

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 Phase 3 Interventional 356 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06958328)

Evidence-Based Quality Improvement to Reduce VA Primary Care Burnout

Burnout, Burnout Syndrome N/A Interventional 203 participants sought

Santa Maria VA Clinic, VA Greater Los Angeles Healthcare System — Santa Maria, California (1.4 mi) · Sponsor: VA Greater Los Angeles Healthcare System

See eligibility & contact on ClinicalTrials.gov (NCT07031245)

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage II, Colorectal Cancer Stage III Phase 3 Interventional 1,057 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT07018869)

Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer

Miscellaneous Neoplasm, Nos, Non-Neoplastic Condition, Nos N/A Interventional 535 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT07091617)

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Pancreatic Acinar Cell Carcinoma, Pancreatic Adenosquamous Carcinoma Phase 2 Interventional 152 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: National Cancer Institute (NCI)

See eligibility & contact on ClinicalTrials.gov (NCT04858334)

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure Phase 2 Interventional 620 participants sought

Comprehensive Cardiovascular Care — Santa Maria, California (1.4 mi) · Sponsor: Pfizer

See eligibility & contact on ClinicalTrials.gov (NCT06991257)

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

Pleural Biphasic Mesothelioma, Pleural Sarcomatoid Mesothelioma Phase 2 Interventional 26 participants sought

PCR Oncology — Arroyo Grande, California (15.3 mi) · Sponsor: Alliance for Clinical Trials in Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05647265)

Imeroprubart in Adult Participants With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Chronic Inflammatory Demyelinating Polyneuropathy Phase 2 Interventional 162 participants sought

Site Number - 1637 — Mission Hills, California (17.1 mi) · Sponsor: Immunovant Sciences GmbH

See eligibility & contact on ClinicalTrials.gov (NCT07032662)

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum N/A Interventional 9,500 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT05080673)

Multi-analyte Blood Test Clinical Trial

Liver Cirrhosis, Liver Cancer N/A Observational 1,200 participants sought

Providence Facey Medical Foundation — Mission Hills, California (17.1 mi) · Sponsor: Helio Genomics

See eligibility & contact on ClinicalTrials.gov (NCT05199259)

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Rectal Cancer Phase 3 Interventional 250 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Canadian Cancer Trials Group

See eligibility & contact on ClinicalTrials.gov (NCT06205485)

S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8, Estrogen Receptor Positive N/A Interventional 739 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: SWOG Cancer Research Network

See eligibility & contact on ClinicalTrials.gov (NCT03723928)

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Prostate Cancer (Adenocarcinoma) Phase 3 Interventional 830 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: Canadian Cancer Trials Group

See eligibility & contact on ClinicalTrials.gov (NCT06592924)

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Head and Neck Squamous Cell Carcinoma, Hypopharyngeal Squamous Cell Carcinoma Phase 2 Interventional 189 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: ECOG-ACRIN Cancer Research Group

See eligibility & contact on ClinicalTrials.gov (NCT02734537)

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma Phase 3 Interventional 880 participants sought

Mission Hope Medical Oncology - Santa Maria — Santa Maria, California (1.4 mi) · Sponsor: NRG Oncology

See eligibility & contact on ClinicalTrials.gov (NCT06580314)

Adherence to Different Exercise Interventions

Exercise Adherence N/A Interventional 60 participants sought

California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo

See eligibility & contact on ClinicalTrials.gov (NCT06024577)

Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs

Diabetes Mellitus, Gestational Diabetes Mellitus (GDM) N/A Interventional 978 participants sought

California Polytechnic State University — San Luis Obispo, California (27.1 mi) · Sponsor: California Polytechnic State University-San Luis Obispo

See eligibility & contact on ClinicalTrials.gov (NCT06988306)

Actively enrolling

Studies you may be able to join near Santa Maria

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility

Google-rated

Top-rated research centers in Santa Maria

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

A.T. Still University - College for Healthy Communities

★ 4.0

1075 Betteravia Rd Suite 201, Santa Maria, CA 93454

(805) 621-7651

Website

"Very clean and the staff very friendly"

— Mario Espinoza, 5★

Ventura Clinical Trials

★ 4.0

1835 Knoll Dr, Ventura, CA 93003

(805) 339-0549

Website

"ALEX WAS SIMPLY AMAZING...VERY PROFESSIONAL YET CARING AS WELL... EXCELLENT BED SIDE MANNER...VERY COMFORTABLE EXPERIENCE.⛑️"

— Manuel Maez, 5★

Labcorp

★ 2.8

1145 E Clark Ave # B, Santa Maria, CA 93455

(805) 934-4498

Website

"I had some blood drawn here and the staff was very friendly and professional. I made an 8:00 a.m. appointment, got there early, and was done and on m…"

— Stephen Herrick, 5★

PCR Oncology

★ 5.0 (4 reviews)

584 Camino Mercado, Arroyo Grande, CA 93420

(805) 474-9143

Website

"Very homely! Staff and doctors are wonderful!"

— jeny fuentes, 5★

Clinical trials in Santa Maria: what's recruiting

The Santa Maria area currently has 89 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Santa Maria, the most active research areas are:

Cancer & Oncology14 studies
Liver & Kidney4 studies
Diabetes & Metabolism2 studies
Heart & Vascular1 studies

Every listing shows the study phase, the recruiting site and its distance from Santa Maria, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Santa Maria

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Santa Maria participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Santa Maria pay?

Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.

Do I need to be sick to join a clinical trial in Santa Maria?

No. Many studies recruit healthy volunteers, especially early-phase studies run at dedicated research centers. Others need participants diagnosed with a specific condition. Every trial lists its eligibility criteria — age range, condition, medications — and the study team screens you before enrollment.

Is compensation for clinical trials taxable?

In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.

How often do new paid studies open in Santa Maria?

Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Santa Maria.

Can I be in more than one clinical trial at a time?

Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Santa Maria typically complete one or two studies per year.

Paid clinical trials near Santa Maria

Other metros within reach

Santa Barbara, CA100 Oxnard, CA128 Bakersfield, CA67 Thousand Oaks, CA667 Visalia, CA2 Fresno, CA167 Santa Clarita, CA2,384 Salinas, CA46

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Santa Maria Bladder Issues Due To Spinal Cord Injury in Santa Maria All conditions

More of CA

Long Beach3,373 Torrance3,260 Fullerton3,257 Anaheim3,199 Garden Grove3,191 Pomona3,156 Glendale2,966 Los Angeles2,950 Huntington Beach2,870 Santa Clarita2,384 Hayward2,256 Oakland2,247

New paid studies open every week

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