Data sourced from ClinicalTrials.gov (NIH registry) Updated weekly IRB-supervised studies only
Home/WI/Appleton
Updated October 2026 from ClinicalTrials.gov

Paid Clinical Trials in Appleton, WI

Studies commonly pay $75 to $4,500 per completed study

148 clinical trials are currently recruiting participants within 30 miles of Appleton. Listings below come straight from the official NIH registry, alongside the area's top-rated research centers with real Google reviews.

148studies recruiting
2+research centers nearby
2condition categories
Live from the NIH registry

Studies recruiting near Appleton right now

Top 25 of 148 recruiting studies, sorted by proximity — each links to its official registry page

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8 Phase 2 Interventional 146 participants sought
Ascension Northeast Wisconsin-Saint Elizabeth Cancer Center-Appleton — Appleton, Wisconsin (1.7 mi) · Sponsor: Alliance for Clinical Trials in Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05673148)

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Female Reproductive System Neoplasm, Malignant Solid Neoplasm Phase 2 Interventional 70 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06126276)

Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

Metastatic Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma Phase 3 Interventional 364 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT04510597)

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Lymphoplasmacytic Lymphoma, Waldenstrom Macroglobulinemia Phase 2 Interventional 92 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04840602)

A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Non-Small Cell Lung Cancer (NSCLC) Phase 3 Interventional 750 participants sought
HSHS St. Vincent Hospital Regional Cancer Center — Green Bay, Wisconsin (24.7 mi) · Sponsor: Bristol-Myers Squibb
See eligibility & contact on ClinicalTrials.gov (NCT07361510)

Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Phase 2 Interventional 335 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05554406)

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 Phase 3 Interventional 3,680 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06058377)

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

Acute Myeloid Leukemia Phase 2 Interventional 93 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT06672146)

Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief

Neck Pain Musculoskeletal, Neck Pain Treatment N/A Interventional 160 participants sought
Emplify by Bellin Health Ashwaubenon — Green Bay, Wisconsin (24.7 mi) · Sponsor: Baylor University
See eligibility & contact on ClinicalTrials.gov (NCT06906107)

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Lymphoma, Non-Hodgkin, Multiple Myeloma Phase 2 Interventional 4,200 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: American Society of Clinical Oncology
See eligibility & contact on ClinicalTrials.gov (NCT02693535)

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Renal Pelvis and Ureter Urothelial Carcinoma Phase 2, Phase 3 Interventional 131 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04628767)

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

High Grade Osteosarcoma, Localized Osteosarcoma Phase 2, Phase 3 Interventional 1,122 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05691478)

Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

Grade 3b Follicular Lymphoma, High Grade B-Cell Lymphoma Phase 2 Interventional 227 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: SWOG Cancer Research Network
See eligibility & contact on ClinicalTrials.gov (NCT05890352)

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Lung Non-Small Cell Carcinoma, Lung Non-Small Cell Squamous Carcinoma Phase 3 Interventional 1,210 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT04267848)

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Metastatic Renal Cell Carcinoma, Stage III Renal Cell Cancer AJCC v8 Phase 2 Interventional 240 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: NRG Oncology
See eligibility & contact on ClinicalTrials.gov (NCT05327686)

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Advanced Colorectal Carcinoma, Advanced Lung Non-Small Cell Carcinoma N/A Observational 800 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: University of Rochester
See eligibility & contact on ClinicalTrials.gov (NCT06073431)

The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials

Cancer N/A Interventional 500 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: Eastern Cooperative Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT06756607)

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma Phase 2, Phase 3 Interventional 992 participants sought
ThedaCare Regional Cancer Center — Appleton, Wisconsin (1.7 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT05987241)

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

Advanced Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma Phase 2 Interventional 46 participants sought
Vince Lombardi Cancer Clinic - Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: National Cancer Institute (NCI)
See eligibility & contact on ClinicalTrials.gov (NCT03191149)

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Anaplastic Kidney Wilms Tumor, Recurrent Kidney Wilms Tumor Phase 2 Interventional 256 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT04322318)

Standardized Application of Feeding Evaluations Using SMART Tool

Infant and Young Child Feeding N/A Interventional 3,500 participants sought
Aurora Medical Center Oshkosh — Oshkosh, Wisconsin (19.1 mi) · Sponsor: Wake Forest University Health Sciences
See eligibility & contact on ClinicalTrials.gov (NCT07136610)

Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

Ganglioneuroblastoma, Ganglioneuroblastoma, Nodular Phase 3 Interventional 750 participants sought
Saint Vincent Hospital Cancer Center Green Bay — Green Bay, Wisconsin (24.7 mi) · Sponsor: Children's Oncology Group
See eligibility & contact on ClinicalTrials.gov (NCT03126916)
Actively enrolling

Studies you may be able to join near Appleton

These studies are recruiting through partner research networks. We may be paid a referral fee if you complete their screening form — this never changes what you pay (nothing) or the compensation the study offers you.

See which clinical studies you may qualify for

A partner research network matches volunteers with studies that are currently enrolling in the United States. You answer a few screening questions about your health and where you live; if a study looks like a fit, its team contacts you to confirm eligibility.

Screening is free and takes a few minutes. Eligibility and any compensation are confirmed by the study team, not by this site.

Check your eligibility
Google-rated

Top-rated research centers in Appleton

Dedicated clinical research sites near you — with their real Google ratings, reviews and contact details

ThedaCare Regional Medical Center-Appleton

★ 3.1
1818 N Meade St, Appleton, WI 54911
(920) 731-4101

NeuroSpine Center Of Wisconsin

★ 4.8
5320 W Michaels Dr, Appleton, WI 54913
(920) 882-8200

Clinical trials in Appleton: what's recruiting

The Appleton area currently has 148 studies open to new participants, according to the ClinicalTrials.gov registry maintained by the U.S. National Institutes of Health. Among the studies closest to Appleton, the most active research areas are:

  • Cancer & Oncology19 studies
  • Liver & Kidney5 studies

Every listing shows the study phase, the recruiting site and its distance from Appleton, and links to the official registry page where eligibility criteria and study contacts are published. Compensation is set by each sponsor: industry surveys report typical payments of $75 to $4,500 per completed study, with short observational studies at the low end and multi-visit or overnight Phase 1 studies at the high end.

How to enroll in a paid study in Appleton

Start with a study whose condition matches your profile — or a healthy-volunteer study if you have no diagnosis. Contact the research site through the registry page, complete a short phone screen, then attend an in-person screening visit. If you qualify, the study team walks you through the informed consent document, which details every procedure, risk and payment before you commit. You can withdraw at any point, and enrollment is always free.

Appleton participants can also register with the dedicated research centers listed above — many maintain volunteer databases and call when a matching study opens — or sign up for our email alert below to hear when a new study starts recruiting within 30 miles of your ZIP code.

Frequently asked questions

How much do paid clinical trials in Appleton pay?
Compensation varies by study length, procedures and overnight stays. Industry surveys report typical payments from $75 to $4,500 per completed study, with simple observational studies at the low end and multi-week inpatient Phase 1 studies at the high end. Each listing's study team will confirm the exact amount before you enroll.
How do I join a study in Appleton, WI?
Pick a study that matches your profile, contact the research site (or apply through the study links on this page), pass a phone pre-screen, then attend an in-person screening visit. If you qualify, you review and sign the informed consent and the study begins. The process typically takes 1-3 weeks.
Is compensation for clinical trials taxable?
In the U.S., clinical trial compensation is generally considered taxable income, and research sites may issue a 1099 form for payments above $600 in a year. Reimbursements for travel or meals are typically treated differently. Consult a tax professional for your situation.
How often do new paid studies open in Appleton?
Constantly — trials open and close enrollment every week. This page is refreshed weekly from the NIH registry. Join the email alert to be notified when a new study opens within 30 miles of Appleton.
Can I be in more than one clinical trial at a time?
Generally no — most studies exclude participants currently enrolled in another trial, and paid Phase 1 studies enforce a washout period (often 30 days or more) between studies. Frequent healthy volunteers in Appleton typically complete one or two studies per year.

Paid clinical trials near Appleton

Other metros within reach

Green Bay, WI145 Milwaukee, WI699 Madison, WI525 Round Lake Beach, IL468 Rockford, IL112 Muskegon, MI62 Aurora, IL619 Chicago, IL2,429

By condition

Eligibility and exclusions, condition by condition

Alcoholic Liver Disease in Appleton Bladder Issues Due To Spinal Cord Injury in Appleton All conditions

More of WI

Milwaukee699 Madison525 Green Bay145

New paid studies open every week

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